« Previous
Next »
Atherosclerosis
Volume 210, Issue 2
, Pages 337-343
, June 2010
The genetics of statin-induced myopathy
References
- . Who should receive a statin these days? Lessons from recent clinical trials. J Intern Med. 2006;260:305–319
- . An assessment of statin safety by muscle experts. Am J Cardiol. 2006;97:69C–76C
- . Statin-associated myopathy. JAMA. 2003;289:1681–1690
- . Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients—the PRIMO study. Cardiovasc Drugs Ther. 2005;19:403–414
- . Cerivastatin and reports of fatal rhabdomyolysis. N Engl J Med. 2002;346:539–540
- . Current overview of statin-induced myopathy. Am J Med. 2004;116:408–416
- . Managing statin myopathy. Endocrinol Metab Clin North Am. 2009;38:121–136
- Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia. J Pathol. 2006;210:94–102
- . The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol. 2007;49:2231–2237
- . Statin myopathy as a metabolic muscle disease. Expert Rev Cardiovasc Ther. 2008;6:971–978
- Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle. J Lipid Res. 2007;48:646–655
- High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. Clin Pharmacol Ther. 2005;78:60–68
- . Changes in ubiquitin proteasome pathway gene expression in skeletal muscle with exercise and statins. Arterioscler Thromb Vasc Biol. 2005;25:2560–2566
- In vivo and in vitro characterization of skeletal muscle metabolism in patients with statin-induced adverse effects. Arthritis Rheum. 2006;55:551–557
- . Selenoprotein synthesis and side-effects of statins. Lancet. 2004;363:892–894
- Genetic risk factors associated with lipid-lowering drug-induced myopathies. Muscle Nerve. 2006;34:153–162
- SLCO1B1 variants and statin-induced myopathy—a genomewide study. N Engl J Med. 2008;359:789–799
- . Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences. Clin Pharmacokinet. 1997;32:403–425
- . Statin and statin-fibrate use was significantly associated with increased myositis risk in a managed care population. J Clin Epidemiol. 2007;60:812–818
- . Statin safety: lessons from new drug applications for marketed statins. Am J Cardiol. 2006;97:44C–51C
- . Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Clin Pharmacol Ther. 2007;82:726–733
- . Pharmacogenomics of human OATP transporters. Naunyn Schmiedebergs Arch Pharmacol. 2006;372:432–443
- . SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. Pharmacogenet Genomics. 2006;16:873–879
- Utility of a novel Oatp1b2 knockout mouse model for evaluating the role of Oatp1b2 in the hepatic uptake of model compounds. Drug Metab Dispos. 2008;36:1840–1845
- . SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin. Clin Pharmacol Ther. 2006;80:356–366
- High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). Pharmacogenetics. 2004;14:429–440
- A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy. Drug Metab Pharmacokinet. 2004;19:453–455
- . Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenet Genomics. 2005;15:513–522
- The SLCO1B1*5 genetic variant is associated with statin-induced side effects. J Am Coll Cardiol. 2009;54:1609–1616
- Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics. 1992;2:116–127
- . Pharmacokinetic–pharmacodynamic drug interactions with HMG-CoA reductase inhibitors. Clin Pharmacokinet. 2002;41:343–370
- . Is the cholesterol-lowering effect of simvastatin influenced by CYP2D6 polymorphism?. Lancet. 1997;350:29–30
- Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997;7:193–202
- Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci USA. 1993;90:11825–11829
- . Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J Pharmacol Exp Ther. 1995;274:516–520
- Association of polymorphism in the cytochrome CYP2D6 and the efficacy and tolerability of simvastatin. Clin Pharmacol Ther. 2001;70:546–551
- . Differences in drug pharmacokinetics between East Asians and Caucasians and the role of genetic polymorphisms. J Clin Pharmacol. 2004;44:1083–1105
- Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin. Pharmacol Res. 2007;55:310–317
- ACC/AHA/NHLBI clinical advisory on the use and safety of statins(1) (2). J Am Coll Cardiol. 2002;40:567–572
- . Development and validation of a high-performance liquid chromatography tandem mass spectrometry assay for atorvastatin, ortho-hydroxy atorvastatin, and para-hydroxy atorvastatin in human, dog, and rat plasma. J Am Soc Mass Spectrom. 1999;10:55–66
- . Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage. Pharmacogenet Genomics. 2005;15:415–421
- A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin. J Hum Genet. 2004;49:582–585
- . In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors. Eur J Clin Pharmacol. 1996;50:209–215
- . Rosuvastatin. Drugs. 2002;62:2075–2085
- . Novel statins: pharmacological and clinical results. Cardiovasc Drugs Ther. 2002;16:251–257
- 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circ Res. 1998;83:490–500
- Physiogenomic analysis links serum creatine kinase activities during statin therapy to vascular smooth muscle homeostasis. Pharmacogenomics. 2005;6:865–872
- . NO more muscle fatigue. J Clin Invest. 2009;119:448–450
- The influence of the 5-HT3 receptor antagonist tropisetron on pain in fibromyalgia: a functional magnetic resonance imaging pilot study. Scand J Rheumatol Suppl. 2004;24–27
- Physiogenomic association of statin-related myalgia to serotonin receptors. Muscle Nerve. 2007;36:329–335
- . McArdle's disease presenting with asymmetric, late-onset arm weakness. Muscle Nerve. 2000;23:641–645
- . McArdle disease with rhabdomyolysis induced by rosuvastatin: case report. Arq Neuropsiquiatr. 2007;65:834–837
- . McArdle's disease diagnosed following statin-induced myositis. Ann Clin Biochem. 2004;41:338–340
- . The case of stainless statins. Ann Clin Biochem. 2003;40:576–577
- . Statin-disclosed acid maltase deficiency. J Intern Med. 2005;258:196–197
- Clinical features and new molecular findings in Carnitine Palmitoyltransferase II (CPT II) deficiency. J Neurol Sci. 2008;266:97–103
- Carnitine palmitoyltransferase deficiencies. Mol Genet Metab. 1999;68:424–440
- Harrison's principles of internal medicine. New York: McGraw-Hill; 2009;
- Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects. Mol Aspects Med. 2004;25:495–520
- . The effects of 3-hydroxy-3-methylglutaryl-CoA reductase inhibition on tissue levels of carnitine and carnitine acyltransferase activity in the rabbit. Lipids. 1996;31:867–870
- Genetic characteristics of myoadenylate deaminase deficiency. Ann Neurol. 1998;44:140–143
- Molecular basis of AMP deaminase deficiency in skeletal muscle. Proc Natl Acad Sci USA. 1992;89:6457–6461
- . Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans. J Physiol. 2001;533:881–889
- . A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature. 1990;348:651–653
- . A new mtDNA mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Biochim Biophys Acta. 1991;1097:238–240
- The 3260 mutation in mitochondrial DNA can cause mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS). Muscle Nerve. 1996;19:1603–1604
- . Statins provoking MELAS syndrome. A case report. Eur Neurol. 2007;57:232–235
- Simvastatin-induced rhabdomyolysis followed by a MELAS syndrome. Am J Med. 1993;94:109–110
- . Myotoxicity of lipid-lowering agents in a teenager with MELAS mutation. Pediatr Neurol. 2008;39:426–428
- Mitochondrial DNA depletion syndrome is expressed in amniotic fluid cell cultures. Am J Pathol. 1999;155:67–70
- Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin. Clin Pharmacol Ther. 2007;81:650–653
- Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med. 2002;137:581–585
- . Metabolic muscle disorders and cholesterol-lowering drugs. In: American College of Rheumatology 2004 Meeting (Abstract 1784). 2004;[Ref Type: Abstract]
- A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. Am J Hum Genet. 2006;78:345–349
- . Genetic determinants of statin intolerance. Lipids Health Dis. 2007;6:7
- Increased exposure to statins in patients developing chronic muscle diseases: a 2-year retrospective study. Ann Rheum Dis. 2008;67:614–619
- . Cytosolic Ca2+ increase and cell damage in L6 rat myoblasts by HMG-CoA reductase inhibitors. Biochem Biophys Res Commun. 1994;202:1579–1585
- Ca2+-releasing effect of cerivastatin on the sarcoplasmic reticulum of mouse and rat skeletal muscle fibers. J Pharmacol Sci. 2003;93:279–288
- . Properties of Ca(2+) release induced by clofibric acid from the sarcoplasmic reticulum of mouse skeletal muscle fibres. Br J Pharmacol. 2001;134:719–728
- HMG CoA reductase inhibition reduces sarcolemmal Na(+)-K(+) pump density. Cardiovasc Res. 2000;47:329–335
- . Statin myopathies: pathophysiologic and clinical perspectives. Clin Invest Med. 2001;24:258–272
- . Cyclosporin A, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor. J Neurochem. 1997;68:1142–1149
- . Epidemiology and inheritance of malignant hyperthermia. Int Anesthesiol Clin. 1979;17:119–139
- A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia. Genomics. 1991;11:751–755
- . Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle. Am J Hum Genet. 1997;60:1316–1325
- . Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia. Br J Anaesth. 2001;86:283–287
- . Malignant hyperthermia susceptibility revealed by increased serum creatine kinase concentrations during statin treatment. Eur J Anaesthesiol. 2004;21:572–574
- . A family with dominant hereditary myotonia, muscular hypertrophy, and increased muscular irritability, distinct from myotonia congenita thomsen. Acta Neurol Scand. 1975;51:225–232
- . Benign familial disease with muscle mounding and rippling. J Neurol Neurosurg Psychiatry. 1994;57:344–347
- . Autosomal recessive rippling muscle disease with homozygous CAV3 mutations. Ann Neurol. 2005;57:303–304
- . Rippling muscles and myasthenia gravis with rippling muscles. Arch Neurol. 1996;53:197–199
- Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy. Nat Genet. 1998;18:365–368
- . Physical mapping of the rippling muscle disease locus. Genomics. 1999;55:268–274
- . Rippling muscle disease: a review. Muscle Nerve. 2002;(Suppl. 11):S103–S107
- . Sporadic rippling muscle disease unmasked by simvastatin. Muscle Nerve. 2006;34:478–481
- Immune-mediated necrotizing myopathy associated with statins. Muscle Nerve. 2009;
☆ No funding was received for this project.
PII: S0021-9150(09)00990-3
doi: 10.1016/j.atherosclerosis.2009.11.033
© 2009 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Atherosclerosis
Volume 210, Issue 2
, Pages 337-343
, June 2010
