Atherosclerosis
Volume 210, Issue 2 , Pages 372-380 , June 2010

Obovatol from Magnolia obovata inhibits vascular smooth muscle cell proliferation and intimal hyperplasia by inducing p21Cip1

  • Yong Lim

      Affiliations

    • Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea
    • ,
  • Jin-Sook Kwon

      Affiliations

    • Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
    • ,
  • Dong-Woon Kim

      Affiliations

    • Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
    • ,
  • Seung-Ho Lee

      Affiliations

    • Ginseng Research Center, KT&G Central Research Institute, Daejeon, Republic of Korea
    • ,
  • Rho-Kwan Park

      Affiliations

    • Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
    • ,
  • Jung-Jin Lee

      Affiliations

    • College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju, Republic of Korea
    • ,
  • Jin-Tae Hong

      Affiliations

    • College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju, Republic of Korea
    • ,
  • Hwan-Soo Yoo

      Affiliations

    • College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju, Republic of Korea
    • ,
  • Byoung-Mog Kwon

      Affiliations

    • Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
    • ,
  • Yeo-Pyo Yun

      Affiliations

    • College of Pharmacy, Research Center for Bioresource and Health, Chungbuk National University, Cheongju, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 43 261 2821; fax: +82 43 268 2732.

Received 1 June 2009 ,Revised 24 November 2009 ,Accepted 24 November 2009.

References 

  1. Ross R. Cell biology of atherosclerosis. Annu Rev Physiol. 1995;57:791–804
  2. Braun-Dullaeus RC, Mann MJ, Dzau VJ. Cell cycle progression: new therapeutic target for vascular proliferative disease. Circulation. 1998;98:82–89
  3. Morgan DO. Principles of CDK regulation. Nature. 1995;374:131–134
  4. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell. 1995;81:323–330
  5. Peter M, Herskowitz I. Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell. 1994;79:181–184
  6. Morishita R, Gibbons GH, Ellison KE, et al. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest. 1994;93:1458–1464
  7. Yang ZY, Simari RD, Perkins ND, et al. Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc Natl Acad Sci USA. 1996;93:7905–7910
  8. el-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993;75:817–825
  9. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993;75:805–816
  10. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981–2002. J Nat Prod. 2003;66:1022–1037
  11. Jiang F, Dusting GJ. Natural phenolic compounds as cardiovascular therapeutics: potential role of their antiinflammatory effects. Curr Vasc Pharmacol. 2003;1:135–156
  12. Ito K, Iida T, Ichino K, et al. Obovatol and obovatal, novel biphenyl ether lignans from the leaves of Magnolia obovata Thunb. Chem Pharm Bull (Tokyo). 1982;30:3347–3353
  13. Pyo MK, Lee Y, Yun-Choi HS. Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata. Arch Pharm Res. 2002;25:325–328
  14. Hwang EI, Kwon BM, Lee SH, et al. Obovatols, new chitin synthase 2 inhibitors of Saccharomyces cerevisiae from Magnolia obovata. J Antimicrob Chemother. 2002;49:95–101
  15. Choi MS, Lee SH, Cho HS, et al. Inhibitory effect of obovatol on nitric oxide production and activation of NF-kappaB/MAP kinases in lipopolysaccharide-treated RAW 264.7cells. Eur J Pharmacol. 2007;556:181–189
  16. Kwon BM, Kim MK, Lee SH, et al. Acyl-CoA: cholesterol acyltransferase inhibitors from Magnolia obovata. Planta Med. 1997;63:550–551
  17. Lo YC, Teng CM, Chen CF, Chen CC, Hong CY. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol. 1994;47:549–553
  18. Pollman MJ, Hall JL, Gibbons GH. Determinants of vascular smooth muscle cell apoptosis after balloon angioplasty injury. Influence of redox state and cell phenotype. Circ Res. 1999;84:113–121
  19. Szocs K, Lassegue B, Sorescu D, et al. Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol. 2002;22:21–27
  20. Lim Y, Kim TJ, Jin YR, et al. Epothilone B inhibits neointimal formation after rat carotid injury through the regulation of cell cycle-related proteins. J Pharmacol Exp Ther. 2007;321:648–655
  21. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest. 1983;49:327–333
  22. Sollott SJ, Cheng L, Pauly RR, et al. Taxol inhibits neointimal smooth muscle cell accumulation after angioplasty in the rat. J Clin Invest. 1995;95:1869–1876
  23. Kim DW, Kwon JS, Kim YG, et al. Novel oral formulation of paclitaxel inhibits neointimal hyperplasia in a rat carotid artery injury model. Circulation. 2004;109:1558–1563
  24. Driscoll B, T’Ang A, Hu YH, et al. Discovery of a regulatory motif that controls the exposure of specific upstream cyclin-dependent kinase sites that determine both conformation and growth suppressing activity of pRb. J Biol Chem. 1999;274:9463–9471
  25. Waga S, Hannon GJ, Beach D, Stillman B. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature. 1994;369:574–578
  26. Erlinge D. Extracellular ATP: a growth factor for vascular smooth muscle cells. Gen Pharmacol. 1998;31:1–8
  27. Slanina J, Glatz Z. Separation procedures applicable to lignan analysis. J Chromatogr B Anal Technol Biomed Life Sci. 2004;812:215–229
  28. Lee SK, Kim HN, Kang YR, et al. Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis. Bioorg Med Chem. 2008;16:8397–8402
  29. Seo JJ, Lee SH, Lee YS, et al. Anxiolytic-like effects of obovatol isolated from Magnolia obovata: involvement of GABA/benzodiazepine receptors complex. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1363–1369
  30. Chen JH, Wu CC, Hsiao G, Yen MH. Magnolol induces apoptosis in vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 2003;368:127–133
  31. Chen YL, Lin KF, Shiao MS, et al. Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbits. Basic Res Cardiol. 2001;96:353–363
  32. Knudsen ES, Wang JY. Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J Biol Chem. 1996;271:8313–8320
  33. Macleod KF, Sherry N, Hannon G, et al. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 1995;9:935–944
  34. Grana X, Reddy EP. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene. 1995;11:211–219
  35. Hunter T, Pines J. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell. 1994;79:573–582
  36. Liu Y, Martindale JL, Gorospe M, Holbrook NJ. Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway. Cancer Res. 1996;56:31–35
  37. Weinstein IB. Relevance of cyclin D1 and other molecular markers to cancer chemoprevention. J Cell Biochem Suppl. 1996;25:23–28
  38. Sherr CJ. G1 phase progression: cycling on cue. Cell. 1994;79:551–555
  39. Tanner FC, Yang ZY, Duckers E, et al. Expression of cyclin-dependent kinase inhibitors in vascular disease. Circ Res. 1998;82:396–403
  40. Fang F, Newport JW. Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes. Cell. 1991;66:731–742
  41. Chang MW, Barr E, Lu MM, Barton K, Leiden JM. Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. J Clin Invest. 1995;96:2260–2268
  42. Chung JK, Lee T, Jung IM, et al. Expression of cell cycle regulators during smooth muscle cell proliferation after balloon catheter injury of rat artery. J Korean Med Sci. 2004;19:327–332

PII: S0021-9150(09)00994-0

doi: 10.1016/j.atherosclerosis.2009.11.037

Atherosclerosis
Volume 210, Issue 2 , Pages 372-380 , June 2010

Article Tools

* Image Usage & Resolution