Atherosclerosis
Volume 210, Issue 2 , Pages 422-429 , June 2010

Caspase-1 recognizes extended cleavage sites in its natural substrates

Received 17 September 2009 ,Revised 19 November 2009 ,Accepted 9 December 2009.

References 

  1. Hansson GK. Inflammation atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1695
  2. Yang XF. Factors regulating apoptosis and homeostasis of CD4+CD25highFOXP3+ regulatory T cells are new therapeutic targets. Front Biosci. 2008;13:1472–1499
  3. Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol. 2009;7:99–109
  4. Tschopp J, Martinon F, Burns K. NALPs: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol. 2003;4:95–104
  5. Li J, Yuan J. Caspases in apoptosis and beyond. Oncogene. 2008;27:6194–6206
  6. Degterev A, Yuan J. Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol. 2008;9:378–390
  7. Schechter I, Berger A. On the size of the active site in proteases. I. Papain. Biochem Biophys Res Commun. 1967;27:157–162
  8. Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell. 2002;9:459–470
  9. Thornberry NA, Rano TA, Peterson EP, et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem. 1997;272:17907–17911
  10. Timmer JC, Salvesen GS. Caspase substrates. Cell Death Differ. 2007;14:66–72
  11. Yang XF, Mirkovic D, Zhang S, et al. Processing sites are different in the generation of HLA-A2.1-restricted, T cell reactive tumor antigen epitopes and viral epitopes. Int J Immunopathol Pharmacol. 2006;19:853–870
  12. Yin Y, Yan Y, Jiang X, et al. Inflammasomes are differentially expressed in cardiovascular and other tissues. Int J Immunopathol Pharmacol. 2009;22:311–322
  13. Eisenberg E, Levanon EY. Human housekeeping genes are compact. Trends Genet. 2003;19:362–365
  14. Rosner B. Hypothesis testing: one-sample inference. In:  Rosner B editors. Fundamentals of biostatistics.. Australia, Canada, Mexico, Singapore, Spain, United Kingdom, United States: Duxbury Press; 2000;p. 211–271
  15. Wada K, Wada Y, Ishibashi F, Gojobori T, Ikemura T. Codon usage tabulated from the GenBank genetic sequence data. Nucleic Acids Res. 1992;20(Suppl.):2111–2118
  16. Shao W, Yeretssian G, Doiron K, Hussain SN, Saleh M. The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J Biol Chem. 2007;282:36321–36329
  17. Gasteiger E, Hoogland C, Gattiker A, et al. Protein identification and analysis tools on the ExPASy Server. In: Walker J.M., editors. The proteomics protocols handbook. Humana Press; 2005. p. 571–607.
  18. Garcia-Calvo M, Peterson EP, Leiting B, et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem. 1998;273:32608–32613
  19. Schulz JB, Weller M, Moskowitz MA. Caspases as treatment targets in stroke and neurodegenerative diseases. Ann Neurol. 1999;45:421–429
  20. Li M, Ona VO, Guegan C, et al. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science. 2000;288:335–339
  21. Friedlander RM. Apoptosis and caspases in neurodegenerative diseases. N Engl J Med. 2003;348:1365–1375
  22. Lamkanfi M, Kanneganti TD, Van Damme P, et al. Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics. 2008;7:2350–2363
  23. Basak S, Hoffmann A. Crosstalk via the NF-kappaB signaling system. Cytokine Growth Factor Rev. 2008;19:187–197

PII: S0021-9150(09)01025-9

doi: 10.1016/j.atherosclerosis.2009.12.017

Atherosclerosis
Volume 210, Issue 2 , Pages 422-429 , June 2010

Article Tools

* Image Usage & Resolution