Atherosclerosis
Volume 210, Issue 2 , Pages 452-457 , June 2010

Carotid wall thickness and stroke risk in patients with asymptomatic internal carotid stenosis

  • Mauro Silvestrini

      Affiliations

    • Neurological Clinic, Marche Polytechnic University, Ancona, Italy
    • Corresponding Author InformationCorresponding author at: Clinica Neurologica, Università Politecnica delle Marche, Via Conca 1, 60020 Ancona, Italy. Tel.: +39 071 5964532; fax: +39 071 887262.
  • ,
  • Claudia Cagnetti

      Affiliations

    • Neurological Clinic, Marche Polytechnic University, Ancona, Italy
  • ,
  • Patrizio Pasqualetti

      Affiliations

    • SeSMIT-Medical Statistics & Information Technology, AFaR-Fatebenefratelli Hospital at Isola Tiberina, Rome, Italy
    • Casa di cura “San Raffaele-Cassino” & IRCCS “San Raffaele-Pisana”, Rome, Italy
  • ,
  • Carlo Albanesi

      Affiliations

    • Neurological Clinic, Marche Polytechnic University, Ancona, Italy
  • ,
  • Claudia Altamura

      Affiliations

    • Clinical Neurology, Campus Bio-Medico University of Rome, Italy
  • ,
  • Chiara Lanciotti

      Affiliations

    • Neurological Clinic, Marche Polytechnic University, Ancona, Italy
  • ,
  • Marco Bartolini

      Affiliations

    • Neurological Clinic, Marche Polytechnic University, Ancona, Italy
  • ,
  • Francesca Mattei

      Affiliations

    • SeSMIT-Medical Statistics & Information Technology, AFaR-Fatebenefratelli Hospital at Isola Tiberina, Rome, Italy
  • ,
  • Leandro Provinciali

      Affiliations

    • Neurological Clinic, Marche Polytechnic University, Ancona, Italy
  • ,
  • Fabrizio Vernieri

      Affiliations

    • Clinical Neurology, Campus Bio-Medico University of Rome, Italy

Received 11 September 2009 ,Revised 19 December 2009 ,Accepted 22 December 2009.

References 

  1. Biller J, Feinberg WM, Castaldo JE, et al. A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke. 1998;29:554–562
  2. Nadareishvili ZG, Rothwell PM, Beletsky V, Pagniello A, Norris JW. Long-term risk of stroke and other vascular events in patients with asymptomatic carotid artery stenosis. Arch Neurol. 2002;59:1162–1166
  3. Chambers BR, Donnan GA. Carotid endarterectomy for asymptomatic carotid stenosis. Cochrane Database Syst Rev. 2005;4:CD001923
  4. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study . Endarterectomy for asymptomatic carotid stenosis. JAMA. 1995;273:1421–1428
  5. Warlow C. Surgical treatment of asymptomatic carotid stenosis. Cerebrovasc Dis. 1996;6(Suppl. 1):7–14
  6. Kappelle LJ, Eliasziw M, Fox AJ, Sharpe BL, Barnett HJM. Importance of intracranial atherosclerotic disease in patients with symptomatic stenosis of the internal carotid artery. Stroke. 1999;30:282–286
  7. Markus H, Cullinane M. Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion. Brain. 2001;124:457–467
  8. Hennerici M, Rautenberg W, Sitzer G, Schwartz A. Transcranial Doppler ultrasound for the assessment of intracranial arterial flow velocity, part I: examination techniques and normal values. Surg Neurol. 1987;27:439–448
  9. Craven TE, Ryu JE, Espeland MA, et al. Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis: a case–control study. Circulation. 1999;82:1230–1242
  10. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999;340:14–22
  11. Gortler M, Niethammer R, Widder B. Differentiating subtotal carotid artery stenoses from occlusion by colour-coded duplex sonography. J Neurol. 1994;241:301–305
  12. de Bray JM, Baud JM, Delanoy P, et al. Reproducibility in ultrasonic characterization of carotid plaques. Cerebrovasc Dis. 1998;8:273–277
  13. Inzitari D, Eliasziw M, Gates P, et al. The causes and risk of stroke in patients with asymptomatic internal-carotid artery stenosis. N Engl J Med. 2000;342:1693–1700
  14. Touboul PJ, Hennerici MG, Meairs S, et al. Mannheim carotid intima–media thickness consensus (2004–2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis. 2007;23:75–80
  15. O’Leary DH, Polak JF, Kronmal RA, et al. Thickening of the carotid wall. A marker for atherosclerosis in the elderly?. Stroke. 1996;27:224–231
  16. Rothman K, Greenland S. Modern epidemiology. Philadelphia: Lippincott-Raven Publisher; 1998;
  17. Tsivgoulis G, Spengos K, Manta P, et al. Validation of the ABCD score in identifying individuals at high early risk of stroke after a transient ischemic attack: a hospital-based case series study. Stroke. 2006;37:2892–2897
  18. Wattanakit K, Folsom AR, Chambless LE, Nieto FJ. Risk factors for cardiovascular event recurrence in the Atherosclerosis Risk in Communities (ARIC) study. Am Heart J. 2005;149:606–612
  19. Kablak-Ziembicka A, Przewlocki T, Pieniazek P, et al. The role of carotid intima–media thickness assessment in cardiovascular risk evaluation in patients with polyvascular atherosclerosis. Atherosclerosis. 2009;(August):[Epub ahead of print] PMID: 19762025
  20. Dick P, Sherif C, Sabeti S, Amighi J, Minar E, Schillinger M. Gender differences in outcome of conservatively treated patients with asymptomatic high grade carotid stenosis. Stroke. 2005;36:1178–1183
  21. Liapis CD, Kakisis JD, Kostakis AG. Carotid stenosis: factors affecting symptomatology. Stroke. 2001;32:2782–2786
  22. Sabeti S, Schlager O, Exner M, et al. Progression of carotid stenosis detected by duplex ultrasonography predicts adverse outcomes in cardiovascular high-risk patients. Stroke. 2007;38:2887–2894
  23. Kakkos SK, Sabetai M, Tegos T, et al. Silent embolic infarcts on computed tomography brain scans and risk of ipsilateral hemispheric events in patients with asymptomatic internal carotid artery stenosis. J Vasc Surg. 2009;49:902–909
  24. Ritter MA, Dittrich R, Thoenissen N, Ringelstein EB, Nabavi DG. Prevalence and prognostic impact of microembolic signals in arterial sources of embolism. A systematic review of the literature. J Neurol. 2008;255:953–961
  25. Rerkasem K, Shearman CP, Williams JA, et al. C-reactive protein is elevated in symptomatic compared with asymptomatic patients with carotid artery disease. Eur J Vasc Endovasc Surg. 2002;23:505–509
  26. Streifler JY, Rosenberg N, Chetrit A, et al. Cerebrovascular events in patients with significant stenosis of the carotid artery are associated with hyperhomocysteinemia and platelet antigen-1 (Leu33Pro) polymorphism. Stroke. 2001;32:2753–2758
  27. Lewis SJ. Prevention and treatment of atherosclerosis: a practitioner's guide for 2008. Am J Med. 2009;122(Suppl. 1):S38–S50
  28. Hodis HN, Mack WJ, Dustin L, et al. High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial. Stroke. 2009;40:730–736

PII: S0021-9150(09)01084-3

doi: 10.1016/j.atherosclerosis.2009.12.033

Atherosclerosis
Volume 210, Issue 2 , Pages 452-457 , June 2010