Atherosclerosis
Volume 210, Issue 2 , Pages 438-444 , June 2010

Impact of HDL on adipose tissue metabolism and adiponectin expression

  • Sophie Van Linthout

      Affiliations

    • Charité, University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, Germany
    • Berlin-Brandenburg Center for Regenerative Therapies, Charité, University-Medicine Berlin, Campus Virchow, Berlin, Germany
    • ,
  • Anna Foryst-Ludwig

      Affiliations

    • Charité, University-Medicine Berlin, Center for Cardiovascular Research, Berlin, Germany
    • ,
  • Frank Spillmann

      Affiliations

    • Charité, University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, Germany
    • ,
  • Jun Peng

      Affiliations

    • Charité, University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, Germany
    • ,
  • Yingmei Feng

      Affiliations

    • Center for Molecular and Vascular Biology, University of Leuven, Belgium
    • ,
  • Marco Meloni

      Affiliations

    • Charité, University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, Germany
    • ,
  • Eline Van Craeyveld

      Affiliations

    • Center for Molecular and Vascular Biology, University of Leuven, Belgium
    • ,
  • Ulrich Kintscher

      Affiliations

    • Charité, University-Medicine Berlin, Center for Cardiovascular Research, Berlin, Germany
    • ,
  • Heinz-Peter Schultheiss

      Affiliations

    • Charité, University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, Germany
    • ,
  • Bart De Geest

      Affiliations

    • Center for Molecular and Vascular Biology, University of Leuven, Belgium
    • ,
  • Carsten Tschöpe

      Affiliations

    • Charité, University-Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, Germany
    • Berlin-Brandenburg Center for Regenerative Therapies, Charité, University-Medicine Berlin, Campus Virchow, Berlin, Germany
    • Corresponding Author InformationCorresponding author at: Department of Cardiology & Pneumology, Charité, University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany. Tel.: +49 30 8445 4780; fax: +49 30 8445 4648.

Received 27 June 2009 ,Revised 26 November 2009 ,Accepted 3 January 2010.

References 

  1. Ouchi N, Ohishi M, Kihara S, et al. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension. 2003;42:231–234
  2. Pischon T, Girman CJ, Hotamisligil GS, et al. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA. 2004;291:1730–1737
  3. Van Linthout S, Spillmann F, Riad A, et al. Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy. Circulation. 2008;117:1563–1573
  4. Van Linthout S, Spillmann F, Lorenz M, et al. Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor. Hypertension. 2009;53:682–687
  5. Zietz B, Herfarth H, Paul G, et al. Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes. FEBS Lett. 2003;545:103–104
  6. Schulze MB, Rimm EB, Shai I, et al. Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes. Diabetes Care. 2004;27:1680–1687
  7. Cnop M, Havel PJ, Utzschneider KM, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia. 2003;46:459–469
  8. Cote M, Mauriege P, Bergeron J, et al. Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men. J Clin Endocrinol Metab. 2005;90:1434–1439
  9. Verges B, Petit JM, Duvillard L, et al. Adiponectin is an important determinant of apoA-I catabolism. Arterioscler Thromb Vasc Biol. 2006;26:1364–1369
  10. von Eynatten M, Hamann A, Twardella D, et al. Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease. Clin Chem. 2006;52:853–859
  11. Tschritter O, Fritsche A, Thamer C, et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes. 2003;52:239–243
  12. de Souza JA, Vindis C, Hansel B, et al. Metabolic syndrome features small, apolipoprotein A-I-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity. Atherosclerosis. 2008;197:84–94
  13. Catalano G, Julia Z, Frisdal E, et al. Torcetrapib differentially modulates the biological activities of HDL2 and HDL3 particles in the reverse cholesterol transport pathway. Arterioscler Thromb Vasc Biol. 2009;29:268–275
  14. Baratta R, Amato S, Degano C, et al. Adiponectin relationship with lipid metabolism is independent of body fat mass: evidence from both cross-sectional and intervention studies. J Clin Endocrinol Metab. 2004;89:2665–2671
  15. Fong BS, Rodrigues PO, Salter AM, et al. Characterization of high density lipoprotein binding to human adipocyte plasma membranes. J Clin Invest. 1985;75:1804–1812
  16. Wu A, Hinds CJ, Thiemermann C. High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications. Shock. 2004;21:210–221
  17. Tsuchihashi H, Yamamoto H, Maeda K, et al. Circulating concentrations of adiponectin, an endogenous lipopolysaccharide neutralizing protein, decrease in rats with polymicrobial sepsis. J Surg Res. 2006;134:348–353
  18. Van Linthout S, Collen D, De Geest B. Effect of promoters and enhancers on expression, transgene DNA persistence, and hepatotoxicity after adenoviral gene transfer of human apolipoprotein a-I. Hum Gene Ther. 2002;13:829–840
  19. Van Linthout S, Lusky M, Collen D, et al. Persistent hepatic expression of human apo A-I after transfer with a helper-virus independent adenoviral vector. Gene Ther. 2002;9:1520–1528
  20. De Geest B, Zhao Z, Collen D, et al. Effects of adenovirus-mediated human apo A-I gene transfer on neointima formation after endothelial denudation in apo E-deficient mice. Circulation. 1997;96:4349–4356
  21. De Geest B, Van Linthout S, Collen D. Sustained expression of human apo A-I following adenoviral gene transfer in mice. Gene Ther. 2001;8:121–127
  22. Jacobs F, Van Craeyveld E, Feng Y, et al. Adenoviral low density lipoprotein receptor attenuates progression of atherosclerosis and decreases tissue cholesterol levels in a murine model of familial hypercholesterolemia. Atherosclerosis. 2008;201:289–297
  23. Schupp M, Clemenz M, Gineste R, et al. Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity. Diabetes. 2005;54:3442–3452
  24. Penfornis P, Marette A. Inducible nitric oxide synthase modulates lipolysis in adipocytes. J Lipid Res. 2005;46:135–142
  25. De Geest B, Snoeys J, Van Linthout S, et al. Elimination of innate immune responses and liver inflammation by PEGylation of adenoviral vectors and methylprednisolone. Hum Gene Ther. 2005;16:1439–1451
  26. Pereira RI, Draznin B. Inhibition of the phosphatidylinositol 3’-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes. Metabolism. 2005;54:1636–1643
  27. Cong L, Chen K, Li J, et al. Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes. Biochem J. 2007;403:519–525
  28. Guha M, Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem. 2002;277:32124–32132
  29. Schabbauer G, Tencati M, Pedersen B, et al. PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. Arterioscler Thromb Vasc Biol. 2004;24:1963–1969
  30. de Haas CJ, Poppelier MJ, van Kessel KP, et al. Serum amyloid P component prevents high-density lipoprotein-mediated neutralization of lipopolysaccharide. Infect Immun. 2000;68:4954–4960
  31. Whiteman EL, Cho H, Birnbaum MJ. Role of Akt/protein kinase B in metabolism. Trends Endocrinol Metab. 2002;13:444–451
  32. Phan J, Peterfy M, Reue K. Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. J Biol Chem. 2004;279:29558–29564
  33. Lu B, Lu Y, Moser AH, et al. LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2008;295:E1502–E1509
  34. Chien JY, Jerng JS, Yu CJ, et al. Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis. Crit Care Med. 2005;33:1688–1693
  35. Mineo C, Shaul PW. Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair. Trends Cardiovasc Med. 2007;17:156–161
  36. Feng Y, Jacobs F, Van Craeyveld E, et al. Human ApoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008;28:278–283
  37. Teruel T, Hernandez R, Lorenzo M. Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes. 2001;50:2563–2571
  38. Kern PA, Di Gregorio GB, Lu T, et al. Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes. 2003;52:1779–1785
  39. Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941–946
  40. Berg AH, Combs TP, Du X, et al. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 2001;7:947–953
  41. Ouchi N, Kihara S, Arita Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation. 2001;103:1057–1063
  42. Ouchi N, Kihara S, Arita Y, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation. 2000;102:1296–1301
  43. Gupta H, Dai L, Datta G, et al. Inhibition of lipopolysaccharide-induced inflammatory responses by an apolipoprotein AI mimetic peptide. Circ Res. 2005;97:236–243

PII: S0021-9150(10)00002-X

doi: 10.1016/j.atherosclerosis.2010.01.001

Atherosclerosis
Volume 210, Issue 2 , Pages 438-444 , June 2010

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