Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound

Miyoshi, Toru; Onoue, Go; Hirohata, Atsushi; Hirohata, Satoshi; Usui, Shinichi; Hina, Kazuyoshi; Kawamura, Hiroshi; Doi, Masayuki; Kusano, Kengo Fukushima; Kusachi, Shozo; Ninomiya, Yoshifumi

doi:10.1016/j.atherosclerosis.2010.01.032

« Previous Next »Atherosclerosis
Volume 211, Issue 1 , Pages 164-169, July 2010

Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound

Toru Miyoshi
- Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan
- Corresponding author. Tel.: +81 86 235 7129; fax: +81 86 222 7768.
Go Onoue
- Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Atsushi Hirohata
- Department of Cardiology, Sakakibara Heart Institute of Okayama, Okayama, Japan
Satoshi Hirohata
- Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan
Shinichi Usui
- Department of Medical Technology, Okayama University Graduate School of Health Sciences, Okayama, Japan
Kazuyoshi Hina
- Department of Cardiology, Sakakibara Heart Institute of Okayama, Okayama, Japan
Hiroshi Kawamura
- Department of Cardiology, Sakakibara Heart Institute of Okayama, Okayama, Japan
Masayuki Doi
- Department of Cardiology, Kagawa Prefectural Central Hospital, Kagawa, Japan
Kengo Fukushima Kusano
- Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Shozo Kusachi
- Department of Medical Technology, Okayama University Graduate School of Health Sciences, Okayama, Japan
Yoshifumi Ninomiya
- Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan

Received 6 August 2009; received in revised form 18 January 2010; accepted 25 January 2010. published online 02 March 2010.

Abstract

Objectives

Adipocyte fatty acid-binding protein (A-FABP) has been shown to have an effect on insulin resistance, lipid metabolism, and atherosclerosis in animals. We therefore investigated the association between the serum A-FABP level and coronary atherosclerosis.

Methods

One hundred twenty-five consecutive patients with coronary artery disease (CAD) were enrolled after coronary angiography. Plaque volume in non-culprit coronary arteries was determined using intravascular ultrasound and expressed as percent plaque volume (%PV). Voluntary blood donors (n=120), matched for age and gender, served as controls. Serum levels of A-FABP, adiponectin, and inflammatory markers were measured by enzyme-linked immunosorbent assay.

Results

The serum A-FABP level in CAD patients was significantly higher than in control subjects (median [25th–75th percentiles], 27.2 [20.5–37.1]ng/mL vs. 18.9 [14.6–24.5]ng/mL) (p<0.01). Serum A-FABP showed 0.74 of the area under the curve in the receiver operating characteristic curve for the detection of CAD, with 76% specificity and 65% sensitivity with a cut-off value of 20.1ng/mL. Further, in CAD patients, serum A-FABP had a significant correlation with %PV in all subjects (r=0.33, p<0.01). Serum A-FABP was positively correlated with the body mass index, serum interleukin-6 and high-sensitive CRP, and negatively correlated with HDL-cholesterol and serum adiponectin in CAD patients. Stepwise regression analysis revealed that serum A-FABP was independently associated with %PV.

Conclusion

Increased serum A-FABP was significantly associated with a greater coronary plaque burden. Our findings revealed that the measurement of serum A-FABP could be utilized for the evaluation of the extent of coronary atherosclerosis.

Keywords: Adipocyte, Fatty acid-binding protein, Coronary artery disease, Intravascular ultrasound