Atherosclerosis
Volume 211, Issue 1 , Pages 77-83 , July 2010

5′-Nitro-indirubinoxime inhibits inflammatory response in TNF-α stimulated human umbilical vein endothelial cells

  • Eun-Jung Kim

      Affiliations

    • Department of Biochemistry, Dongguk University College of Oriental Medicine, 707 Seokjang-dong, Gyeongju-si, Gyeongsangbuk-do 780-714, Gyeongju, Republic of Korea
    • ,
  • Won-Hwan Park

      Affiliations

    • Department of Diagnostics, Dongguk University College of Oriental Medicine, Gyeongju, Republic of Korea
    • ,
  • Sang-Gun Ahn

      Affiliations

    • Department of Pathology, Chosun University College of Dentistry, Gwangju, Republic of Korea
    • ,
  • Jung-Hoon Yoon

      Affiliations

    • Department of Pathology, Chosun University College of Dentistry, Gwangju, Republic of Korea
    • ,
  • Si-Wouk Kim

      Affiliations

    • Department of Environmental Engineering, Chosun University College of Engineering, Gwangju, Republic of Korea
    • ,
  • Soo-A Kim

      Affiliations

    • Department of Biochemistry, Dongguk University College of Oriental Medicine, 707 Seokjang-dong, Gyeongju-si, Gyeongsangbuk-do 780-714, Gyeongju, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 54 770 2836; fax: +82 54 770 2281.

Received 19 August 2008 ,Revised 21 January 2010 ,Accepted 27 January 2010.

References 

  1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340:115–126
  2. Fan J, Watanabe T. Inflammatory reactions in the pathogenesis of atherosclerosis. J Atheroscler Thromb. 2003;10:63–71
  3. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301–314
  4. Modur V, Zimmerman GA, Prescott SM, et al. Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and-independent mitogen-activated protein kinase cascades. J Biol Chem. 1996;271:13094–13102
  5. Satriano JA, Shuldiner M, Hora K, et al. Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase. J Clin Invest. 1993;92:1564–1571
  6. Sica A, Wang JM, Colotta F, et al. Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor. J Immunol. 1990;144:3034–3038
  7. Rollins BJ, Yoshimura T, Leonard EJ, et al. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am J Pathol. 1990;136:1229–1233
  8. Takeya M, Yoshimura T, Leonard EJ, et al. Detection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an anti-monocyte chemoattractant protein-1 monoclonal antibody. Hum Pathol. 1993;24:534–539
  9. Nelken NA, Coughlin SR, Gordon D, et al. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest. 1991;88:1121–1127
  10. Huber AR, Kunkel SL, Todd RF, et al. Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science. 1991;254:99–102
  11. Gerszten RE, Garcia-Zepeda EA, Lim YC, et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. 1999;398:718–723
  12. Boisvert WA, Santiago R, Curtiss LK, et al. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest. 1998;101:353–363
  13. Zhang ZN, Liu EK, Zheng TL, et al. Treatment of chronic myelocytic leukemia (CML) by traditional Chinese medicine and Western medicine alternately. J Tradit Chin Med. 1985;5:246–248
  14. Xiao Z, Hao Y, Liu B, et al. Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China. Leuk Lymphoma. 2002;43:1763–1768
  15. Kim SA, Kim YC, Kim SW, et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007;13:253–259
  16. Kunikata T, Tatefuji T, Aga H, et al. Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity. Eur J Pharmacol. 2000;410:93–100
  17. Koch AE, Kunkel SL, Pearce WH, et al. Enhanced production of the chemotactic cytokines interleukin-8 and monocyte chemoattractant protein-1 in human abdominal aortic aneurysms. Am J Pathol. 1993;142:1423–1431
  18. Gerszten RE, Mach F, Sauty A, et al. Chemokines, leukocytes, and atherosclerosis. J Lab Clin Med. 2000;136:87–92
  19. Kurihara T, Warr G, Loy J, et al. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med. 1997;186:1757–1762
  20. Gu L, Okada Y, Clinton SK, et al. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell. 1998;2:275–281
  21. Zhou Z, Gengaro P, Wang W, et al. Role of NF-κB and PI 3-kinase/Akt in TNF-α-induced cytotoxicity in microvascular endothelial cells. Am J Physiol Renal Physiol. 2008;295:F932–F941
  22. Carr MW, Roth SJ, Luther E, et al. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci USA. 1994;91:3652–3656
  23. Rollins BJ. Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease. Mol Med Today. 1996;2:198–204
  24. Blankenberg S, Barbaux S, Tiret L. Adhesion molecules and atherosclerosis. Atherosclerosis. 2003;170:191–203
  25. Poston RN, Haskard DO, Coucher JR, et al. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol. 1992;140:665–673
  26. Sethi G, Ahn KS, Sandur SK, et al. Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem. 2006;281:23425–23435
  27. Hajra L, Evans AI, Chen M, et al. The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation. Proc Natl Acad Sci USA. 2000;97:9052–9057
  28. Kempe S, Kestler H, Lasar A, et al. NF-kappa B controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program. Nucleic Acids Res. 2005;33:5308–5319
  29. Taub DD. Chemokine-leukocyte interactions. The voodoo that they do so well. Cytokine Growth Factor Rev. 1996;7:355–376
  30. Steffens S, Mach F. Inflammation and atherosclerosis. Herz. 2004;29:741–748

PII: S0021-9150(10)00088-2

doi: 10.1016/j.atherosclerosis.2010.01.040

Atherosclerosis
Volume 211, Issue 1 , Pages 77-83 , July 2010

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