Atherosclerosis
Volume 211, Issue 1 , Pages 303-307 , July 2010

Leptin is associated with the size of the apolipoprotein(a) particle in African tribal populations living on fish or vegetarian diet

  • Mikolaj Winnicki

      Affiliations

    • Medical University of Gdansk, Poland
    • University of Padova, Italy
    • Mayo Clinic, Rochester, MN, United States
  • ,
  • Massimo Puato

      Affiliations

    • University of Padova, Italy
  • ,
  • Virend K. Somers

      Affiliations

    • Mayo Clinic, Rochester, MN, United States
  • ,
  • Alberto Zambon

      Affiliations

    • University of Padova, Italy
  • ,
  • Santica M. Marcovina

      Affiliations

    • University of Washington, Seattle, WA, United States
  • ,
  • Marcello Rattazzi

      Affiliations

    • University of Padova, Italy
  • ,
  • Bradley G. Phillips

      Affiliations

    • University of Iowa, Iowa City, IA, United States
  • ,
  • Paolo Pauletto

      Affiliations

    • University of Padova, Italy
    • Corresponding Author InformationCorresponding author at: Department of Clinical & Experimental Medicine, University of Padova, Via. Giustiniani 2, 35126 Padova, Italy. Tel.: +39 049 821 2278; fax: +39 049 875 4179.

Received 10 July 2009 ,Revised 18 January 2010 ,Accepted 27 January 2010.

References 

  1. Jialal I. Evolving lipoprotein risk factors: lipoprotein(a) and oxidized low-density lipoprotein. Clin Chem. 1998;44:1827–1832
  2. Erqou S, Kaptoge S, Perry PL, et al. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA. 2009;302:412–423
  3. Kamstrup PR, Tybjaerg-Hansen A, Steffensen R, Nordestgaard BG. Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. JAMA. 2009;301:2331–2339
  4. Sandholzer C, Hallman DM, Saha N, et al. Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups. Hum Genet. 1991;86:607–614
  5. Lundstam U, Herlitz J, Karlsson T, Linden T, Wiklund O. Serum lipids, lipoprotein(a) level, and apolipoprotein(a) isoforms as prognostic markers in patients with coronary heart disease. J Intern Med. 2002;251:111–118
  6. Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation. 2001;104:3052–3056
  7. Soderberg S, Ahren B, Jansson JH, et al. Leptin is associated with increased risk of myocardial infarction. J Intern Med. 1999;246:409–418
  8. Soderberg S, Ahren B, Stegmayr B, et al. Leptin is a risk marker for first-ever hemorrhagic stroke in a population-based cohort. Stroke. 1999;30:328–337
  9. Winnicki M, Somers VK, Accurso V, et al. Fish-rich diet, leptin, and body mass. Circulation. 2002;106:289–291
  10. Marcovina SM, Kennedy H, Bittolo Bon G, et al. Fish intake, independent of apo(a) size, accounts for lower plasma lipoprotein(a) levels in Bantu fishermen of Tanzania: The Lugalawa Study. Arterioscler Thromb Vasc Biol. 1999;19:1250–1256
  11. O’Rourke L, Yeaman SJ, Shepherd PR. Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways. Diabetes. 2001;50:955–961
  12. Silaste ML, Rantala M, Alfthan G, et al. Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). Arterioscler Thromb Vasc Biol. 2004;24:498–503
  13. Shin MJ, Blanche PJ, Rawlings RS, Fernstrom HS, Krauss RM. Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins. Am J Clin Nutr. 2007;85:1527–1532
  14. Pauletto P, Puato M, Caroli MG, et al. Blood pressure and atherogenic lipoprotein profiles of fish-diet and vegetarian villagers in Tanzania: the Lugalawa study. Lancet. 1996;348:784–788
  15. Flower L, Ahuja RH, Humphries SE, Mohamed-Ali V. Effects of sample handling on the stability of interleukin 6, tumour necrosis factor-alpha and leptin. Cytokine. 2000;12:1712–1716
  16. Marcovina SM, Zhang ZH, Gaur VP, Albers JJ. Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein(a) alleles between American blacks and whites. Biochem Biophys Res Commun. 1993;191:1192–1196
  17. van der Hoek YY, Wittekoek ME, Beisiegel U, Kastelein JJ, Koschinsky ML. The apolipoprotein(a) kringle IV repeats which differ from the major repeat kringle are present in variably-sized isoforms. Hum Mol Genet. 1993;2:361–366
  18. Childs MT, King IB, Knopp RH. Divergent lipoprotein responses to fish oils with various ratios of eicosapentaenoic acid and docosahexaenoic acid. Am J Clin Nutr. 1990;52:632–639
  19. Boerwinkle E, Leffert CC, Lin J, Lackner C, Chiesa G, Hobbs HH. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest. 1992;90:52–60
  20. Kang C, Dominguez M, Loyau S, Miyata T, Durlach V, Angles-Cano E. Lp(a) particles mold fibrin-binding properties of apo(a) in size-dependent manner: a study with different-length recombinant apo(a), native Lp(a), and monoclonal antibody. Arterioscler Thromb Vasc Biol. 2002;22:1232–1238
  21. Montoya MT, Porres A, Serrano S, et al. Fatty acid saturation of the diet and plasma lipid concentrations, lipoprotein particle concentrations, and cholesterol efflux capacity. Am J Clin Nutr. 2002;75:484–491
  22. Doi T, Liu M, Seeley RJ, Woods SC, Tso P. Effect of leptin on intestinal apolipoprotein AIV in response to lipid feeding. Am J Physiol Regul Integr Comp Physiol. 2001;281:R753–759
  23. Schuller E, Patel N, Item C, et al. The genetic background modifies the effects of the obesity mutation, ‘fatty’, on apolipoprotein gene regulation in rat liver. Int J Obes Relat Metab Disord. 2000;24:460–467
  24. Javor ED, Ghany MG, Cochran EK, et al. Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy. Hepatology. 2005;41:753–760
  25. Sampath H, Ntambi JM. Polyunsaturated fatty acid regulation of gene expression. Nutr Rev. 2004;62:333–339
  26. Bendinelli P, Piccoletti R, Maroni P. Leptin rapidly activates PPARs in C2C12 muscle cells. Biochem Biophys Res Commun. 2005;332:719–725
  27. Teivainen-Laedre PA, Eliassen KA, Sletten M, Smith AJ, Berg K. Reduced LPA expression after peroxisome proliferator-activated receptor alpha (PPARalpha) activation in LPA-YAC transgenic mice. Pathophysiology. 2005;11:201–208
  28. Israelian-Konaraki Z, Reaven PD. Peroxisome proliferator-activated receptor-alpha and atherosclerosis: from basic mechanisms to clinical implications. Cardiol Rev. 2005;13:240–246
  29. Walder K, Hanson RL, Kobes S, Knowler WC, Ravussin E. An autosomal genomic scan for loci linked to plasma leptin concentration in Pima Indians. Int J Obes Relat Metab Disord. 2000;24:559–565
  30. Rubin J, Paultre F, Tuck CH, et al. Apolipoprotein [a] genotype influences isoform dominance pattern differently in African Americans and Caucasians. J Lipid Res. 2002;43:234–244

PII: S0021-9150(10)00089-4

doi: 10.1016/j.atherosclerosis.2010.01.041

Atherosclerosis
Volume 211, Issue 1 , Pages 303-307 , July 2010