Atherosclerosis
Volume 211, Issue 1 , Pages 84-89 , July 2010

Systemic MCP1/CCR2 blockade and leukocyte specific MCP1/CCR2 inhibition affect aortic aneurysm formation differently

  • Vivian de Waard

      Affiliations

    • Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands
    • Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    • These authors contributed equally to the study.
    • Corresponding Author InformationCorresponding author at: Academic Medical Center, Medical Biochemistry, K1-144, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands. Tel.: +31 20 5665129; fax: +31 20 6915519.
    • ,
  • Ilze Bot

      Affiliations

    • Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands
    • These authors contributed equally to the study.
    • ,
  • Saskia C.A. de Jager

      Affiliations

    • Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands
    • ,
  • Sara Talib

      Affiliations

    • Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands
    • ,
  • Kensuke Egashira

      Affiliations

    • Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Margreet R. de Vries

      Affiliations

    • Department of Vascular Surgery, Einthoven Laboratories, Leiden University Medical Center, The Netherlands
    • ,
  • Paul H.A. Quax

      Affiliations

    • Department of Vascular Surgery, Einthoven Laboratories, Leiden University Medical Center, The Netherlands
    • ,
  • Erik A.L. Biessen

      Affiliations

    • Department of Pathology, Cardiovascular Research Institute, University of Maastricht, The Netherlands
    • ,
  • Theo J.C. van Berkel

      Affiliations

    • Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands

Received 9 July 2009 ,Revised 20 November 2009 ,Accepted 28 January 2010.

References 

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  19. Kundumani-Sridharan V, Wang D, Karpurapu M, et al. Suppression of activation of signal transducer and activator of transcription-5B signaling in the vessel wall reduces balloon injury-induced neointima formation. Am J Pathol. 2007;171(October (4)):1381–1394
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  21. Schecter AD, Berman AB, Yi L, et al. MCP-1-dependent signaling in CCR2(−/−) aortic smooth muscle cells. J Leukoc Biol. 2004;75(6):1079–1085
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PII: S0021-9150(10)00090-0

doi: 10.1016/j.atherosclerosis.2010.01.042

Atherosclerosis
Volume 211, Issue 1 , Pages 84-89 , July 2010

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