Atherosclerosis
Volume 211, Issue 1 , Pages 308-314 , July 2010

Postprandial lipid and apolipoprotein responses following three consecutive meals associate with liver fat content in type 2 diabetes and the metabolic syndrome

  • Maarten E. Tushuizen

      Affiliations

    • Department of Endocrinology/Diabetes Center, The Netherlands
  • ,
  • Petra J. Pouwels

      Affiliations

    • Department of Physics & Medical Technology, VU University Medical Center, The Netherlands
  • ,
  • Saskia Bontemps

      Affiliations

    • Department of Endocrinology/Diabetes Center, The Netherlands
  • ,
  • Cees Rustemeijer

      Affiliations

    • Department of Internal Medicine, Hospital Amstelland, Amstelveen, The Netherlands
  • ,
  • Niina Matikainen

      Affiliations

    • Department of Medicine, University of Helsinki, Helsinki, Finland
  • ,
  • Robert J. Heine

      Affiliations

    • Department of Endocrinology/Diabetes Center, The Netherlands
  • ,
  • Marja-Riitta Taskinen

      Affiliations

    • Department of Medicine, University of Helsinki, Helsinki, Finland
  • ,
  • Michaela Diamant

      Affiliations

    • Department of Endocrinology/Diabetes Center, The Netherlands
    • Corresponding Author InformationCorresponding author at: Department of Endocrinology/Diabetes Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. Tel.: +31 204440534; fax: +31 204440530.

Received 11 May 2009 ,Revised 31 January 2010 ,Accepted 1 February 2010.

References 

  1. Tushuizen ME, Diamant M, Heine RJ. Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes. Postgrad Med J. 2005;81:1–6
  2. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298:299–308
  3. Mero N, Malmstrom R, Steiner G, Taskinen MR, Syvanne M. Postprandial metabolism of apolipoprotein B-48- and B-100-containing particles in type 2 diabetes mellitus: relations to angiographically verified severity of coronary artery disease. Atherosclerosis. 2000;150:167–177
  4. Adeli K, Lewis LF. Intestinal lipoprotein overproduction in insulin-resistant states. Curr Opin Lipidol. 2008;19:221–228
  5. Duez H, Pavlic M, Lewis GF. Mechanism of intestinal lipoprotein overproduction in insulin resistant humans. Atheroscler Suppl. 2008;9:33–38
  6. Duez H, Lamarche B, Uffelman KD, et al. Hyperinsulinemia is associated with increased production rate of intestinal apolipoprotein B-48-containing lipoproteins in humans. Arterioscler Thromb Vasc Biol. 2006;26:1357–1363
  7. Hogue JC, Lamarche B, Tremblay AJ, et al. Evidence of increased secretion of apolipoprotein B-48-containing lipoproteins in subjects with type 2 diabetes. J Lipid Res. 2007;48:1336–1342
  8. Robertson MD, Parkes M, Warren BH, et al. Mobilisation of enterocyte fat stores by oral glucose in humans. Gut. 2003;52:834–839
  9. Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844–1850
  10. Kotronen A, Yki-Järvinen H. Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2007;28:27–38
  11. Matikainen N, Mänttäri S, Westerbacka J, et al. Postprandial lipemia associates with liver fat content. J Clin Endocrinol Metab. 2007;92:3052–3059
  12. Iovine C, Vaccaro O, Gentile A, et al. Postprandial triglyceride profile in a population-based sample of type 2 diabetic patients. Diabetologia. 2004;47:19–22
  13. Szczepaniak LS, Babcock EE, Schick F, et al. Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol. 1999;276:E977–E989
  14. Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:2486–97.
  15. Hajer GR, Dallinga-Thie GM, van Vark-van der Zee LC, Visseren FL. The effect of statin alone or in combination with ezetimibe on postprandial lipoprotein composition in obese metabolic syndrome patients. Atherosclerosis. 2009;202:216–224
  16. Otokozawa S, Ai M, Diffenderfer MR, et al. Fasting and postprandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjects. Metabolism. 2009;58:1536–1542
  17. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  18. Tushuizen ME, Bunck MC, Pouwels PJ, et al. Pancreatic fat content and β-cell function in men with and without type 2 diabetes. Diabetes Care. 2007;30:2916–2921
  19. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672–679
  20. Van Beek AP, Van Barlingen HH, De Ruijter-Heijstek FC, et al. Preferential clearance of apoB-48-containing lipoproteins after heparin-induced lipolysis is modulated by lipoprotein lipase activity. J Lipid Res. 1998;39:322–332
  21. Wang H, Eckel RH. Lipoprotein lipase: from gene to obesity. Am J Physiol Endocrinol Metab. 2009;297:E271–E288
  22. Hsieh J, Hayashi AA, Webb J, Adeli K. Postprandial dyslipidemia in insulin resistance: mechanisms and role of intestinal insulin sensitivity. Atheroscler Suppl. 2008;9:7–13
  23. Tiikkainen M, Bergholm R, Vehkavaara S, et al. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes. 2003;52:701–707
  24. Zhang D, Liu ZX, Choi CS, et al. Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance. Proc Natl Acad Sci USA. 2007;104:17075–17080
  25. Chuang CC, Yang RS, Tsai KS, Ho FM, Liu SH. Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signal-regulated protein kinase 1/2, phosphoinositide 3-kinase/Akt, and peroxisome proliferator-activated receptor gamma signaling. Endocrinology. 2007;148:4267–4275
  26. Adiels M, Olofsson SO, Taskinen MR, Borén J. Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2008;28:1225–1236
  27. Su JW, Lambert JE, Clandinin MT, Proctor SD. Impaired postprandial metabolism of apolipoprotein B48-containing remnant particles in normolipidemic subjects with brittle type 1 diabetes. Diabetes Care. 2009;32:e21

PII: S0021-9150(10)00100-0

doi: 10.1016/j.atherosclerosis.2010.02.002

Atherosclerosis
Volume 211, Issue 1 , Pages 308-314 , July 2010