Atherosclerosis
Volume 212, Issue 1 , Pages 30-31 , September 2010

Reduction of endoplasmic reticulum stress—A novel mechanism of action of statins in the protection against atherosclerosis

  • Lício A. Velloso

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +55 19 35218022; fax: +55 19 35218950.

Received 25 February 2010

References 

  1. Erbay E, Babaev VR, Mayers JR, et al. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med. 2009;15:1383–1391
  2. Preiss D, Sattar N. Lipids, lipid modifying agents and cardiovascular risk: a review of the evidence. Clin Endocrinol (Oxf). 2009;70:815–828
  3. Amarenco P, Labreuche J. Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention. Lancet Neurol. 2009;8:453–463
  4. Endo A. A gift from nature: the birth of the statins. Nat Med. 2008;14:1050–1052
  5. Blum A, Shamburek R. The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis. Atherosclerosis. 2009;203:325–330
  6. Ishibashi S, Brown MS, Goldstein JL, et al. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest. 1993;92:883–893
  7. Chen JC, Wu ML, Huang KC, Lin WW. HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression. Cardiovasc Res. 2008;80:138–150
  8. Zhao H, Liao Y, Minamino T, et al. Inhibition of cardiac remodeling by pravastatin is associated with amelioration of endoplasmic reticulum stress. Hypertens Res. 2008;31:1977–1987

PII: S0021-9150(10)00327-8

doi: 10.1016/j.atherosclerosis.2010.04.036

Atherosclerosis
Volume 212, Issue 1 , Pages 30-31 , September 2010

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