Atherosclerosis
Volume 212, Issue 2 , Pages 571-574 , October 2010

Long-term LDL-c lowering in heterozygous familial hypercholesterolemia normalizes carotid intima-media thickness

  • S. Sivapalaratnam

      Affiliations

    • Department of Vascular Medicine, Academic Medical Centre, F4-159.2, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    • These authors contributed equally to the manuscript.
    • Corresponding Author InformationCorresponding author. Tel.: +31 20 566 6396; fax: +31 20 5669343.
  • ,
  • L.L. van Loendersloot

      Affiliations

    • Department of Vascular Medicine, Academic Medical Centre, F4-159.2, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    • Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, The Netherlands
    • These authors contributed equally to the manuscript.
  • ,
  • B.A. Hutten

      Affiliations

    • Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, Amsterdam, The Netherlands
  • ,
  • J.J.P. Kastelein

      Affiliations

    • Department of Vascular Medicine, Academic Medical Centre, F4-159.2, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
  • ,
  • M.D. Trip

      Affiliations

    • Department of Vascular Medicine, Academic Medical Centre, F4-159.2, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
  • ,
  • E. de Groot

      Affiliations

    • Department of Vascular Medicine, Academic Medical Centre, F4-159.2, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Received 9 March 2010 ,Revised 21 June 2010 ,Accepted 24 June 2010.

References 

  1. Goldstein JL, Hobbs HH, Brown MS. Familial hypercholesterolemia. In:  Baudet AL,  Vogelstein B,  Kinzler K,  Atonarakis A,  Ballabio A editor. The metabolic and molecular basis of inherited disease. New York: McGrawHill; 2007;
  2. Huijgen R, Vissers MN, Defesche JC, Lansberg PJ, Kastelein JJ, Hutten BA. Familial hypercholesterolemia: current treatment and advances in management. Expert Rev Cardiovasc Ther. 2008;(6):567–581
  3. van Aalst-Cohen ES, Jansen AC, Tanck MW, et al. Diagnosing familial hypercholesterolaemia: the relevance of genetic testing. Eur Heart J. 2006;(27):2240–2246
  4. Stone NJ, Levy RI, Fredrickson DS, Verter J. Coronary artery disease in 116 kindred with familial type II hyperlipoproteinemia. Circulation. 1974;(49):476–488
  5. Slack J. Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states. Lancet. 1969;(2):1380–1382
  6. Havel RJ, Hunninghake DB, Illingworth DR, et al. Lovastatin (mevinolin) in the treatment of heterozygous familial hypercholesterolemia. A multicenter study. Ann Intern Med. 1987;(107):609–615
  7. Smilde TJ, van WS, Wollersheim H, Trip MD, Kastelein JJ, Stalenhoef AF. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet. 2001;(357):577–581
  8. de Sauvage Nolting PR, Buirma RJ, Hutten BA, Kastelein JJ. Two-year efficacy and safety of simvastatin 80mg in familial hypercholesterolemia (the Examination of Probands and Relatives in Statin Studies With Familial Hypercholesterolemia [ExPRESS FH]). Am J Cardiol. 2002;(90):181–184
  9. Neil A, Cooper J, Betteridge J, et al. Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study. Eur Heart J. 2008;(29):2625–2633
  10. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;(18):499–502
  11. Groot de E, Hovingh GK, Wiegman A, et al. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation. 2004;(109):III33–III38
  12. Groot de E, Zwinderman AH, van der Steen AF, et al. Variance components analysis of carotid and femoral intima-media thickness measurements. REGRESS Study Group, Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study. Ultrasound Med Biol. 1998;(24):825–832
  13. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation. 2007;(115):459–467
  14. Versmissen J, Oosterveer DM, Yazdanpanah M, et al. Efficacy of statins in familial hypercholesterolaemia: a long term cohort study. BMJ. 2008;(337):a2423
  15. Espeland MA, O’Leary DH, Terry JG, et al. Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors. Curr Control Trials Cardiovasc Med. 2005;(6):3
  16. Kastelein JJ, Akdim F, Stroes ES, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med. 2008;(358):1431–1443

PII: S0021-9150(10)00497-1

doi: 10.1016/j.atherosclerosis.2010.06.040

Atherosclerosis
Volume 212, Issue 2 , Pages 571-574 , October 2010