Atherosclerosis
Volume 212, Issue 2 , Pages 512-515 , October 2010

Levels of asymmetrical dimethylarginine are predictive of brachial artery flow-mediated dilation 6 years later. The Cardiovascular Risk in Young Finns Study

  • Hannu Päivä

      Affiliations

    • Division of Emergency, University Hospital of Tampere, Tampere, Finland
    • Department of Clinical Chemistry, Tampere University Hospital and University of Tampere Medical School, Tampere, Finland
    • Corresponding Author InformationCorresponding author at: Division of Emergency, University Hospital of Tampere, PO Box 2000, 33521 Tampere, Finland. Tel.: +358 3 311 611; fax: +358 3 311 65346.
    • ,
  • Mika Kähönen

      Affiliations

    • Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
    • ,
  • Terho Lehtimäki

      Affiliations

    • Department of Clinical Chemistry, Tampere University Hospital and University of Tampere Medical School, Tampere, Finland
    • Medical School, University of Tampere, Tampere, Finland
    • ,
  • Georg Alfthan

      Affiliations

    • National Institute of Health and Welfare, Helsinki, Finland
    • ,
  • Jorma Viikari

      Affiliations

    • Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
    • ,
  • Reijo Laaksonen

      Affiliations

    • Department of Clinical Chemistry, Tampere University Hospital and University of Tampere Medical School, Tampere, Finland
    • Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland
    • ,
  • Nina Hutri-Kähönen

      Affiliations

    • Department of Pediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland
    • ,
  • Tomi Laitinen

      Affiliations

    • Department of Clinical Physiology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
    • ,
  • Leena Taittonen

      Affiliations

    • Department of Pediatrics, Vaasa Central Hospital, Vaasa, Finland
    • ,
  • Olli T. Raitakari

      Affiliations

    • Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
    • Department of Clinical Physiology, Turku University Hospital and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    • ,
  • Markus Juonala

      Affiliations

    • Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

Received 9 May 2010 ,Revised 19 June 2010 ,Accepted 21 June 2010.

References 

  1. Valkonen VP, Päivä H, Salonen JT, et al. Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine. Lancet. 2001;358:2127–2128
  2. Zoccali C, Bode-Böger S, Mallamaci F, et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study. Lancet. 2001;358:2113–2117
  3. Böger RH. Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond. Ann Med. 2006;38:126–136
  4. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524–526
  5. Böger RH, Bode-Böger S, Szuba A, et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation. 1998;98:1842–1847
  6. Perticone F, Sciacqua A, Maio R, et al. Asymmetric dimethylarginine, l-arginine, and endothelial dysfunction in essential hypertension. J Am Coll Cardiol. 2005;46:518–523
  7. Juonala M, Viikari JSA, Alfthan G, et al. Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in The Cardiovascular Risk in Young Finns Study. Circulation. 2007;116:1367–1373
  8. Cockcroft DW, Gault MH, Cockcroft DW, et al. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41
  9. Teerlink T, Nijveldt RJ, de Jong S, et al. Determination of arginine, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography. Anal Biochem. 2002;303:131–137
  10. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1992;362:801–809
  11. Ardigo D, Stuehlinger M, Franzini L, et al. ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk. Eur J Clin Invest. 2007;37:263–269
  12. Yasuda S, Miyazaki S, Kanda M, et al. Intensive treatment of risk factors in patients with type-2 diabetes mellitus is associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synthase. Eur Heart J. 2006;27:1159–1165
  13. Cardounel AJ, Xia Y, Zweier JL. Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin. J Biol Chem. 2005;280:7540–7549
  14. Brunini T, Moss M, Siqueira M, et al. Inhibition of l-arginine transport in platelets by asymmetric dimethylarginine and N-monomethyl-l-arginine: effect of arterial hypertension. Clin Exp Pharmacol Physiol. 2004;31:738–740
  15. Cardounel AJ, Cui H, Samouilov A, et al. Evidence for the pathophysiological role of andogenous methylarginines in regulation of endothelial NO production and vascular function. J Biol Chem. 2007;282:879–887

PII: S0021-9150(10)00498-3

doi: 10.1016/j.atherosclerosis.2010.06.041

Atherosclerosis
Volume 212, Issue 2 , Pages 512-515 , October 2010

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