Atherosclerosis
Volume 212, Issue 2 , Pages 674-681 , October 2010

Altered calcium homeostasis is correlated with the presence of metabolic syndrome and diabetes in middle-aged and elderly Korean subjects: The Chungju Metabolic Disease Cohort study (CMC study)

  • Mee Kyoung Kim

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Guilsun Kim

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Eun Hee Jang

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Hyuk Sang Kwon

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Ki Hyun Baek

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Ki Won Oh

      Affiliations

    • Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
  • ,
  • Jin Hee Lee

      Affiliations

    • Department of Preventive Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Kun-Ho Yoon

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Won Chul Lee

      Affiliations

    • Department of Preventive Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Kang Woo Lee

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Ho Young Son

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • ,
  • Moo Il Kang

      Affiliations

    • Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    • Corresponding Author InformationCorresponding author at: Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Ku, Seoul, 137-040, Republic of Korea. Tel.: +82 2 2258 6006; fax: +82 2 599 3589.

Received 1 March 2010 ,Revised 16 June 2010 ,Accepted 7 July 2010.

References 

  1. Hagström E, Lundgren E, Rastad J, Hellman P. Metabolic abnormalities in patients with normocalcemic hyperparathyroidism detected at a population-based screening. Eur J Endocrinol. 2006;155:33–39
  2. Hagström E, Lundgren E, Lithell H, et al. Normalized dyslipidaemia after parathyroidectomy in mild primary hyperparathyroidism: population-based study over five years. Clin Endocrinol. 2002;56:253–260
  3. Ahlström T, Hagström E, Larsson A, et al. Correlation between plasma calcium, parathyroid hormone (PTH) and the metabolic syndrome (MetS) in a community-based cohort of men and women. Clin Endocrinol. 2009;71:673–678
  4. Hjelmesaeth J, Hofsø D, Aasheim ET, et al. Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study. Cardiovasc Diabetol. 2009;8:7
  5. Reis JP, von Mühlen D, Kritz-Silverstein D, Wingard DL, Barrett-Connor E. Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care. 2007;30:1549–1555
  6. Kim MK, Kang MI, Oh KW, et al. The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects. Clin Endocrinol; in press.
  7. Lee DM, Rutter MK, O’Neill TW, et al. European Male Ageing Study Group Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men. Eur J Endocrinol. 2009;161:947–954
  8. Kesteloot H, Geboers J. Calcium and blood pressure. Lancet. 1982;1:813–815
  9. Lind L, Jakobsson S, Lithell H, Wengle B, Ljunghall S. Relation of serum calcium concentration to metabolic risk factors for cardiovascular disease. BMJ. 1988;297:960–963
  10. Jorde R, Sundsfjord J, Fitzgerald P, Bønaa KH. Serum calcium and cardiovascular risk factors and diseases: the Tromsø study. Hypertension. 1999;34:484–490
  11. De Bacquer D, De Henauw S, De Backer G, Kornitzer M. Epidemiological evidence for an association between serum calcium and serum lipids. Atherosclerosis. 1994;108:193–200
  12. Wareham NJ, Byrne CD, Carr C, et al. Glucose intolerance is associated with altered calcium homeostasis: a possible link between increased serum calcium concentration and cardiovascular disease mortality. Metabolism. 1997;46:1171–1177
  13. Hagström E, Hellman P, Lundgren E, Lind L, Arnlöv J. Serum calcium is independently associated with insulin sensitivity measured with euglycaemic–hyperinsulinaemic clamp in a community-based cohort. Diabetologia. 2007;50:317–324
  14. Sun G, Vasdev S, Martin GR, Gadag V, Zhang H. Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and beta-cell function in the Newfoundland population. Diabetes. 2005;54:3336–3339
  15. Lind L, Skarfors E, Berglund L, Lithell H, Ljunghall S. Serum calcium: a new, independent, prospective risk factor for myocardial infarction in middle-aged men followed for 18 years. J Clin Epidemiol. 1997;50:967–973
  16. Taylor WH, Khaleeli AA. Coincident diabetes mellitus and primary hyperparathyroidism. Diabetes Metab Res Rev. 2001;17:175–180
  17. Levy J, Stern Z, Gutman A, et al. Plasma calcium and phosphate levels in an adult noninsulin-dependent diabetic population. Calcif Tissue Int. 1986;39:316–318
  18. Procopio M, Magro G, Cesario F, et al. The oral glucose tolerance test reveals a high frequency of both impaired glucose tolerance and undiagnosed Type 2 diabetes mellitus in primary hyperparathyroidism. Diabet Med. 2002;19:958–961
  19. Ahn YJ, Lee JE, Cho NH, et al. Validation and calibration of semi-quantitative food frequency questionnaire. Korean J Community Nutr. 2004;9:173–182
  20. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  21. Grundy SM, Cleeman JI, Daniels SR, et al. American Heart Association; National Heart, Lung, and Blood Institute Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart. Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–2752
  22. Curry DL, Bennett LL, Grodsky GM. Requirement for calcium ion in insulin secretion by the perfused rat pancreas. Am J Physiol. 1968;214:174–178
  23. Rasouli M, Kiasari AM. Serum calcium and phosphorus associate with the occurrence and severity of angiographically documented coronary heart disease, possibly through correlation with atherogenic (apo)lipoproteins. Clin Chem Lab Med. 2006;44:43–50
  24. Jendryczko A, Pardela M. Abnormal effect of sera from patients with atherosclerosis on calcium influx into normal erythrocytes. Cor Vasa. 1993;34:428–433
  25. Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC. Regulation of adiposity by dietary calcium. FASEB J. 2000;14:1132–1138
  26. Sampath V, Havel PJ, King JC. Calcium supplementation does not alter lipid oxidation or lipolysis in overweight/obese women. Obesity. 2008;16:2400–2404
  27. Taniguchi A, Kataoka K, Kono T, et al. Parathyroid hormone-induced lipolysis in human adipose tissue. J Lipid Res. 1987;28:490–494
  28. McCarty MF, Thomas CA. PTH excess may promote weight gain by impeding catecholamine-induced lipolysis—implications for the impact of calcium, vitamin D, and alcohol on body weight. Med Hypotheses. 2003;61:535–542
  29. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92:2017–2029
  30. Cho GJ, Park HT, Shin JH, et al. Calcium intake is inversely associated with metabolic syndrome in postmenopausal women: Korea National Health and Nutrition Survey, 2001 and 2005. Menopause. 2009;16:992–997
  31. Rojhani A, Kies CV. Selected nutrient intakes and blood serum mineral concentrations of elderly humans fed regular and sweet acidophilus milks. J Nutr Elder. 1994;13:35–56
  32. Block GA, Spiegel DM, Ehrlich J, et al. Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis. Kidney Int. 2005;68:1815–1824
  33. Reid IR, Bolland MJ, Grey A. Does calcium supplementation increase cardiovascular risk? Clin Endocrinol 2010; in press.
  34. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94:26–34

PII: S0021-9150(10)00508-3

doi: 10.1016/j.atherosclerosis.2010.07.005

Atherosclerosis
Volume 212, Issue 2 , Pages 674-681 , October 2010