Pentraxin 3: A novel and independent prognostic marker in ischemic stroke

Ryu, Wi-Sun; Kim, Chi Kyung; Kim, Beom Joon; Kim, Chulho; Lee, Seung-Hoon; Yoon, Byung-Woo

doi:10.1016/j.atherosclerosis.2011.11.036

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Volume 220, Issue 2 , Pages 581-586, February 2012

Pentraxin 3: A novel and independent prognostic marker in ischemic stroke

Wi-Sun Ryu
- Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
- Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
Chi Kyung Kim
- Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
- Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
Beom Joon Kim
- Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
- Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
Chulho Kim
- Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
- Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
- Department of Neurology, Hallym University Sacred Heart Hospital, Chuncheon, Republic of Korea
Seung-Hoon Lee
- Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
- Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
- These authors contributed equally.
- Corresponding author at: Department of Neurology, Seoul National University Hospital, 28 Yongon-dong, Jongno-gu, Seoul 110-744, Republic of Korea. Tel.: +82 2 2072 1014; fax: +82 2 3672 7553.
Byung-Woo Yoon
- Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea
- Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
- These authors contributed equally.
- Corresponding author at: Department of Neurology, Seoul National University Hospital, 28 Yongon-dong, Jongno-gu, Seoul 110-744, Republic of Korea. Tel.: +82 2 2072 2875; fax: +82 2 3672 7553.

Received 2 May 2011; received in revised form 13 November 2011; accepted 22 November 2011. published online 19 December 2011.

Abstract

Objective

Pentraxin 3 (PTX3) is one of the pattern-recognition receptors related to the initial step of the immune response with C-reactive protein, but the physiologic and pathologic functions are not fully understood. The purpose of the current study was to determine the impact of PTX3 levels on mortality after ischemic stroke.

Methods

We consecutively enrolled 376 patients who had ischemic stroke between September 2004 and September 2006. The patients were divided into tertiles according to PTX3 levels. Cox regression analysis was used to determine hazard ratios (HRs) and 95% confidence intervals (CIs) of the PTX3 tertiles for all-cause mortality with adjustment for traditional risk factors and laboratory variables, including C-reactive protein.

Results

During the follow-up, 19.4% of the patients were deceased. The median PTX3 levels were higher in the deceased patients (18.0 vs. 6.4ng/mL, p<0.001). Based on Cox regression analysis, compared with the first tertile of PTX3, the adjusted HRs of the second and third tertiles for all-cause mortality were 1.24 (95% CI, 0.52–2.98) and 2.64 (95% CI, 1.19–5.85), respectively. When the log-transformed levels of PTX3 were incorporated as continuous variables, higher levels of PTX3 were also associated with an increased mortality (increase per log unit; HR, 1.60; 95% CI, 1.19–2.16).

Conclusions

We showed that higher levels of PTX3 are independently associated with increased mortality after ischemic stroke. Our results suggest that PTX3 may be used as a new powerful prognostic biomarker in patients with ischemic stroke.

Keywords: Pentraxin 3, Ischemic stroke, Mortality