« Previous Next » Atherosclerosis
Volume 221, Issue 1 , Pages 98-105 , March 2012

Increased gene dosage of the Ink4/Arf locus does not attenuate atherosclerosis development in hypercholesterolaemic mice

José J. Fuster
- Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain
- Authors with equal contribution.
Pedro Molina-Sánchez
- Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain
- Authors with equal contribution.
David Jovaní
- Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia-Consejo Superior de Investigaciones Científicas (IBV-CSIC), Jaime Roig 11, 46010 Valencia, Spain
Ángela Vinué
- Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia-Consejo Superior de Investigaciones Científicas (IBV-CSIC), Jaime Roig 11, 46010 Valencia, Spain
Manuel Serrano
- Spanish National Cancer Research Center (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain
Vicente Andrés
- Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain
- Corresponding author. Tel.: +34 914531200; fax: +34 914531262.

Received 9 September 2011 ,Revised 12 December 2011 ,Accepted 12 December 2011.

Title	About	Type	File Size
Fig. S1	. Increased Ink4/Arf gene dosage does not affect diet-induced atherosclerosis in male apoE-null mice. Male apoE−/− (n=8) and apoE−/−Super-Ink4/Arf (n=7) mice were fed a high-fat diet for 10 weeks. (A) Atheroma size in the aortic arch and thoracic aorta quantified by en face oil red-O staining. (B) Atheroma size in aortic sinus quantified in hematoxylin/eosin-stained cross-sections (average of 4 cross-sections separated by ∼6μm). Atherosclerotic plaques are delineated by discontinuous lines.		1 MB