Atherosclerosis
Volume 132, Issue 1 , Pages 53-59 , 11 July 1997

Inhibition of smooth muscle cell migration by the p21 cyclin-dependent kinase inhibitor (Cip1)

  • Ryousuke Fukui

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 726 831221; fax: +81 726 831805
    • ,
  • Nobuhiko Shibata

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan
    • ,
  • Eiko Kohbayashi

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan
    • ,
  • Masahiro Amakawa

      Affiliations

    • Kaken Pharmaceutical Company, Limited, Yamashina-ku, Kyoto, 607, Japan
    • ,
  • Daisuke Furutama

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan
    • ,
  • Masaaki Hoshiga

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan
    • ,
  • Nobuyuki Negoro

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan
    • ,
  • Takahiro Nakakouji

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan
    • ,
  • Masaaki Ii

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan
    • ,
  • Tadashi Ishihara

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan
    • ,
  • Nakaaki Ohsawa

      Affiliations

    • First Department of Internal Medicine, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-city, Osaka, 569, Japan

Received 12 September 1996 ,Revised 12 February 1997 ,Accepted 19 March 1997.

References 

  1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801
  2. Sanders M. Molecular and cellular concepts in atherosclerosis. Pharmacol Ther. 1994;61:109
  3. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY. D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol. 1994;14:2066
  4. Matsushime H, Ewen ME, Strom DK, et al.  Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell. 1992;71:323
  5. Sherr CJ. Growth factor-regulated G1 cyclins. Stem Cells Dayt. 1994;12(Suppl 1):47
  6. Simons M, Edelman ER, DeKeyser JL, Langer R, Rosenberg RD. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature. 1992;359:67
  7. Morishita R, Gibbons GH, Ellison KE, et al.  Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci USA. 1993;90:8474
  8. Morishita R, Gibbons GH, Ellison KE, et al.  Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest. 1994;93:1458
  9. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993;75:805
  10. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993;366:704
  11. Polyak K, Lee MH, Erdjument Bromage H, et al.  Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994;78:59
  12. Toyoshima H, Hunter T. p27, A novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 1994;78:67
  13. Chang MW, Barr E, Lu MM, Barton K, Leiden JM. Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty. J Clin Invest. 1995;96:2260
  14. Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene. 1991;108:193
  15. Sasaki Y, Uchida T, Sasaki Y. A variant derived from rabbit aortic smooth muscle: phenotype modulation and restoration of smooth muscle characteristics in cells in culture. J Biochem Tokyo. 1989;106:1009
  16. Sullian TR, Karas RH, Aronovitz M, et al.  Estrogen inhibits the response-to-injury in a mouse carotid artery model. J Clin Invest. 1995;96:2482
  17. Fredersdorf S, Milne AW, Hall PA, Lu X. Characterization of a panel of novel anti-p21Waf1/Cip1 monoclonal antibodies and immunochemical analysis of p21Waf1/Cip1 expression in normal human tissus. Am J Pathol. 1996;148:825
  18. Warnke R, Levy R. Detection of T and B cell antigens hybridoma monoclonal antibodies: a biotin–avidin–horseradish peroxidase method. J Histochem Cytochem. 1980;28:771
  19. Fujio Y, Yamada F, Takahashi K, Shibata N. Altered fibronectin-dependent cell adhesion by PDGF accompanies phenotypic modulation of vascular smooth muscle cells. Biochem Biophys Res Commun. 1993;196:997
  20. Koyama N, Hart CE, Clowes AW. Different functions of the platelet-derived growth factor-alpha and -beta receptors for the migration and proliferation of cultured baboon smooth muscle cells. Circ Res. 1994;75:682
  21. Koyama N, Harada K, Yamamoto A, Morisaki N, Saito Y, Yoshida S. Purification and characterization of an autocrine migration factor for vascular smooth muscle cells (SMC), SMC-derived migration factor. J Biol Chem. 1993;268:13301
  22. Yang ZY, Simari RD, Perkins ND, et al.  Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury. Proc Natl Acad Sci USA. 1996;93:7905
  23. Katayose D, Wersto R, Cowan K, Seth P. Consequences of p53 gene expression by adenovirus vector on cell cycle arrest and apoptosis in human aortic vascular smooth muscle cells. Biochem Biophys Res Commun. 1995;215:446
  24. Stossel TP. On the crawling of animal cells. Science. 1993;260:1086
  25. Mitchison TJ, Cramer LP. Actin-baced cell motility and cell locomotion. Cell. 1996;84:371
  26. Wang J, Walsh K. Resistance to apoptosis conferred by cdk inhibitors during myocyte differentiation. Science. 1996;273:359
  27. Zhang Z, Morla AO, Vuori K, Bauer JS, Juliano RL, Ruoslahti E. The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin. J Cell Biol. 1993;122:235
  28. DiMilla PA, Stone JA, Quinn JA, Albelda SM, Lauffenburger DA. Maximal migration of human smooth mucle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J Cell Biol. 1993;122:729–737
  29. Miyamoto S, Teramoto H, Coso OA, et al.  Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol. 1995;131:791
  30. Meredith J, Takada Y, Fornaro M, Languino LR, Schwartz MA. Inhibition of cell cycle progression by the alternatively spliced integrin b1c. Science. 1995;269:1570
  31. Bussey H. Cell shape determination: a pivotal role for Rho. Science. 1996;272:224
  32. Miura Y, Kikuchi A, Musha T, et al.  Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells. J Biol Chem. 1993;268:510
  33. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 1992;70:401
  34. Takaishi K, Kikuchi A, Kuroda S, Kotani K, Sasaki T, Takai Y. Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol Cell Biol. 1993;13:72
  35. Stasia MJ, Jouan A, Bourmeyster N, Boquet P, Vignais PV. ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility. Biochem Biophys Res Commun. 1991;180:615
  36. Self AJ, Paterson HF, Hall A. Different structural organization of Ras and Rho effector domains. Oncogene. 1993;8:655
  37. Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992;70:389
  38. Hall A. Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu Rev Cell Biol. 1994;10:31
  39. Takai Y, Sasaki T, Tanaka K, Nakanishi H. Rho as a regulator of the cytoskeleton. Trends Biochem Sci. 1995;20:227
  40. Yamamoto M, Marui N, Sakai T, et al.  ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle. Oncogene. 1993;8:1449

PII: S0021-9150(97)00086-5

Atherosclerosis
Volume 132, Issue 1 , Pages 53-59 , 11 July 1997

Article Tools

* Image Usage & Resolution