Atherosclerosis
Volume 132, Issue 1 , Pages 61-67 , 11 July 1997

Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains

  • J.E Ronden

      Affiliations

    • Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands
    • ,
  • M.M.C.L Groenen-van Dooren

      Affiliations

    • Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands
    • ,
  • G Hornstra

      Affiliations

    • Department of Human Biology and Nutrition, Toxicology and Environmental Research Institute, Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands
    • ,
  • C Vermeer

      Affiliations

    • Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P.O. Box 616, 6200 MD Maastricht, Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 43 3881682; fax: +31 43 3670992

Received 16 December 1996 ,Revised 14 March 1997 ,Accepted 19 March 1997.

References 

  1. Vermeer C. Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem J. 1980;266:625–636
  2. Furie B, Furie BC. Molecular basis of vitamin K-dependent γ-carboxylation. Blood. 1990;75:1753–1762
  3. Shearer MJ. Vitamin K. Lancet. 1995;345:229–234
  4. Price PA. Role of vitamin K-dependent proteins in bone metabolism. Annu Rev Nutr. 1988;8:565–583
  5. Hauschka PV, Lian JB, Cole DEC, Gundberg CM. Osteocalcin and matrix Gla protein: vitamin K dependent proteins in bone. Phys Rev. 1989;69:990–1047
  6. Knapen MHJ, Hamulyák K, Vermeer C. The effect of vitamin K supplementation on circulating osteocalcin (bone Gla-protein) and urinary calcium excretion. Ann Int Med. 1989;111:1001–1005
  7. Knapen MHJ, Jie K-SG, Hamulyák K, Vermeer C. Vitamin K-induced changes in markers for osteoblast activitiy and urinary calcium loss. Calcif Tissue Int. 1993;53:81–85
  8. Plantalech L, Guillaumont M, Vergnaud P, Leclercq M, Delmas PD. Impairment of gamma carboxylation of circulating osteocalcin (bone Gla protein) in elderly women. J Bone Miner Res. 1991;6:1211–1216
  9. Hart JP, Catterall A, Dodds RA, et al.  Circulating vitamin K1 levels in fractured neck of femur. Lancet. 1984;ii:283
  10. Hart JP, Shearer MJ, Klenerman L, et al.  Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis. J Clin Endocrinol Metab. 1985;60:1268–1269
  11. Hodges SJ, Pilkington MJ, Shearer MJ, Bitensky L, Chayen J. Age-related changes in the circulating levels of cengeners of vitamin K2, menaquinone-7 and menaquinone-8. Clin Sci. 1990;78:63–66
  12. Hodges SJ, Akesson K, Vergnaud P, Obrant K, Delmas PD. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993;8:1241–1245
  13. Plantalech LC, Chapuy MC, Guillaumont M, Chapuy P, Leclercq M, Delmas PD. Impaired carboxylation of serum osteocalcin in elderly women: effect of vitamin K1 treatment. In: Christiansen C, Overgaard K, editors. Osteoporosis 1990. Copenhagen: Osteopress Aps., 1990:345–347.
  14. Orimo H, Shiraki M, Fujita T, Onomura T, Inoue T, Kushida K. Clinical evaluation of menatetrenone in the treatment of involutional osteoporosis—a double-blind multicenter comparative study with 1 α hydroxy vitamin D3. J Bone Miner Res. 1992;7:S122
  15. Groenen-van Dooren MMCL, Soute BAM, Jie K-SG, Thijssen HHW, Vermeer C. The relative effects of phylloquinone and menaquinone on the blood coagulation factor synthesis in vitamin K-deficient rats. Biochem Pharmacol. 1993;46:433–437
  16. Groenen-van Dooren MMCL, Ronden JE, Soute BAM, Vermeer C. Bioavailability of phylloquinone and menaquinones after oral and colorectal administration in the vitamin K-deficient rat. Biochem Pharmacol. 1995;50:797–801
  17. Hemker HC, Wielders S, Kessels H, Béguin S. Continuous registration of thrombin generation in plasma, its use for the determination of the thrombin potential. Thromb Haemostas. 1993;70:617–624
  18. Heemskerk JWM, Feijge MAH, Kester A, Hornstra G. Dietary fat modifies thromboxane A2-induced stimulation of rat platelets. Biochem J. 1991;278:399–404
  19. Thijssen HHW, Dritty-Reijnders MJ. Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. Br J Nutr. 1994;72:415–425
  20. Hornstra G, Lussenburg RN. Relationship between the type of dietary fatty acid and arterial thrombosis tendency in rats. Atherosclerosis. 1975;22:499–516
  21. Buitenhuis HC, Soute BAM, Vermeer C. Comparison of the vitamins K1, K2 and K3 as cofactors for the hepatic vitamin K-dependent carboxylase. Biochim Biophys Acta. 1990;1034:170–175
  22. Hara K, Akiyama Y, Nakamura T, Murota S, Morita I. The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. Bone. 1995;16:179–184
  23. Kameda T, Miyazawa K, Mori Y, et al.  Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochem Biophys Res Commun. 1996;220:515–519

PII: S0021-9150(97)00087-7

Atherosclerosis
Volume 132, Issue 1 , Pages 61-67 , 11 July 1997

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