Atherosclerosis
Volume 132, Issue 1 , Pages 69-76 , 11 July 1997

Dietary flax seed in prevention of hypercholesterolemic atherosclerosis

Received 17 June 1996 ,Revised 4 February 1997 ,Accepted 13 February 1997.

References 

  1. Görg P, Kakkar VV. Increased uptake of monocyte-treated low density lipoproteins by aortic endothelium in vivo. Atherosclerosis. 1987;65:99
  2. Prisco D, Rogasi PG, Matucci M, et al.  Age related changes in platelet lipid composition. Thromb Res. 1986;44:427
  3. Stuart MJ, Gerrard JM, White JG. Effect of cholesterol on production of thromboxane B2 by platelets in vitro. N Engl J Med. 1980;302:6
  4. Mosconi C, Colli S, Tremoli E. Phosphatidylinositol (PI) and PI-associated arachidonate are elevated in platelet total membranes of type IIa hypercholesterolemic subjects. Atherosclerosis. 1988;72:129
  5. Shattil SJ, Anaya-Galindo R, Bennet J, Colman RW, Cooper RA. Platelet hypersensitivity induced by cholesterol incorporation. J Clin Invest. 1975;55:636
  6. Ruzicka T, Printz MP. Arachidonic acid metabolism in skin: a review. Rev Physiol Biochem Pharmacol. 1984;100:121
  7. Vanden Bosch H. Intracellular phospholipases A. Biochem Biophys Acta. 1980;604:191
  8. Quan-sang KHL, Levenson J, Simon A, Meyer P, Devynck MA. Platelet cytosolic free Ca++ concentration and plasma cholesterol in untreated hypertensives. J Hypertens. 1987;5(Suppl 5):S251
  9. Whatley RE, Nelson P, Zimmerman GA, et al.  The regulation of platelet-activating factor production in endothelial cell: the role of calcium and protein kinase C. J Biol Chem. 1989;264:6325
  10. Heller R, Bussolino F, Ghigo D, et al.  Protein kinase C and cyclic AMP modulate thrombin-induced platelet activating factor synthesis in human endothelial cells. Biochim Biophys Acta. 1991;1093:55
  11. Bussolino F, Camussi G. Platelet-activating factor produced by endothelial cells. A molecule with autocrine and paracrine properties. Eur J Biochem. 1995;229:327
  12. Vogt W, Von Zabern I, Damerau B, Hesse D, Luhmann B, Nolte R. Mechanisms of complement activation by crystalline cholesterol. Mol Immunol. 1985;22:101
  13. Seifert PS, Kazatchkine MD. Generation of complement anaphylatoxins C5b-9 by crystalline cholesterol oxidation derivatives depend on hydroxyl group number and position. Mol Immunol. 1987;24:1303
  14. Greenberg CS, Hammerschmidt DE, Gradock PR, Jacob HS. Atheroma cholesterol activates complement and aggravates granulocytes: possible role in ischemic manifestations of atherosclerosis. Trans Assoc Am Physicians. 1979;92:130
  15. Seifert PS, Hugo F, Hansson GK, Bhakdi S. Prelesional complement activation in experimental atherosclerosis. Terminal C5b-9 complement deposition coincides with cholesterol accumulation in the aortic intima of hypercholesterolemic rabbits. Lab Invest. 1989;60:747
  16. Webster RO, Hong SR, Johnston RB, Henson PM. Biological effects of human complement fragment on C5a and C5a des Arg on neutrophil function. Immunopharmacology. 1980;2:201
  17. Denton C, Lesnik P, Chapman MJ, Ninio E. Phagocytic activation induces formation of platelet activating factor in human monocyte-derived macrophages and in macrophage-derived foam cells. Relevance to the inflammatory reaction in atherogenesis. Eur J Biochem. 1996;236:48
  18. Pignol B, Henane S, Mencia-Huerta JM, Rolapleszynski M, Braquet P. Effect of PAF-acethar (platelet-activating factor) and its specific antagonist, BN52021, on interleukin 1 (IL-1) release and synthesis by rat skin adherent monocytes. Prostaglandins. 1987;33:931
  19. Bonavida B, Mencia-Heurta JM, Braquet P. Effect of platelet-activating factor (PAF) on monocyte activation and production of tumor necrosis factor (INF). Int Arch Allergy Appl Immunol. 1989;88:157
  20. Braquet P, Paubert-Braquet M, Gourgain RH, et al.  PAF/cytokine auto-generated feedback networks in microvascular immune injury: consequences in shock, ischemia and graft rejection. J Lipid Mediator. 1989;1:75
  21. Rouis M, Nigon F, Chapman MJ. Platelet-activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochem Biophys Res Commun. 1998;156:1293
  22. Shaw JO, Pinckard RN, Ferrigni KS, McManus LM, Hanahan DJ. Activation of human neutrophils with 1-0-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphoryl-choline (platelet-activating factor). J Immunol. 1981;127:1250
  23. Stewart AG, Dubbin PN, Harris T, Dusting GJ. Platelet-activating factor may act as a second messenger in the release of eicosanoids and superoxide anions from leucocytes and endothelial cells. Proc Natl Acad Sci USA. 1990;87:3215
  24. Braquet P, Hosfard D, Braquet M, Bourgain R, Bussolino F. Role of cytokines and platelet-activating factor in microvascular immune injury. Int Arch Allerg Appl Immunol. 1989;88:88
  25. Paubert-Braquet M, Longchampt MO, Koltz P, Gutlbaud J. Tumor necrosis factor (TNF) primes human neutrophil (PMN) platelet-activating factor (PAF)-induced superoxide generation. Consequences in promoting PMN-mediated endothelial cell (EC) damages (abstract). Prostaglandins. 1988;35:803
  26. Panganamala RV, Sharma HM, Heikki JC, Geer JC, Cornwell DG. Role of hydroxyl radical scavenger dimethylsulfoxide, alcohols and methional in the inhibition of prostaglandin biosynthesis. Prostaglandins. 1976;11:599
  27. Murota SI, Morita I, Suda N. The control of vascular endothelial cell injury. Ann NY Acad Sci. 1990;598:182
  28. Prasad K, Kalra J. Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am Heart J. 1993;125:958
  29. Prasad K, Kalra J, Lee P. Oxygen free radicals as a mechanism of hypercholesterolemic atherosclerosis: effects of probucol. Int J Angiol. 1994;3:100
  30. Steinberg D. Antioxidants in the prevention of human atherosclerosis. Circulation. 1992;85:2338
  31. Kita T, Nagano Y, Yokode M, et al.  Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci USA. 1987;84:5928
  32. Kuo PT, Wilson AC, Kostis JB, Moreyra AE. Effects of combined probucol-colestipol treatment for familial hypercholesterolemia and coronary artery disease. Am J Cardiol. 1986;57:43H
  33. Evangelou AM. Platelet-activating factor (PAF)—implications for coronary heart and vascular diseases. Prostaglandins Leukotrienes Essent Fatty Acids. 1994;50:1
  34. Feliste R, Perret B, Braquet P, Chap H. Protective effect of BN52021, a specific antagonist of platelet-activating factor (PAF-acether) against diet-induced cholesterol ester deposition in rabbit aorta. Atherosclerosis. 1989;78:151
  35. Ross R. The pathogenesis of atherosclerosis: perspective for the 1990's. Nature. 1993;362:801
  36. Carter J. Flax-seed as a source of alpha-linolenic acid. J Am Coll Nutr. 1993;12:551
  37. Cunnane SC, Ganguli S, Menard C, et al.  High alpha-linolenic acid flax-seed (Linum usit atissimum): some nutritional properties in humans. Br J Nutr. 1993;69:433
  38. Kelley DS, Branch LB, Love JE, Taylor PC, Rivera YM, Iacono JM. Dietary alpha-linolenic acid and immunocompetence in humans. Am J Clin Nutr. 1991;53:40
  39. Hunter JE. n-3 Fatty acids from vegetable oils. Am J Clin Nutr. 1990;51:809
  40. Exler J, Weihrauch JL. Provisional Table on the Content of n-3 Fatty Acids and Other Fat Components in Selected Foods. Washington, DC: US Department of Agriculture, 1985 (Publication HNIS/PT-103).
  41. Cox CP, Wood KL. Selective antagonism of platelet-activating factor (PAF)induced aggregation and secretion of in washed rabbit platelets by CV-3988, L-652731, triazolam and alprazolam. Thromb Res. 1987;47:249
  42. Endress S, Chorbani R, Kelley VE, et al.  The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by monocytes. N Engl J Med. 1989;320:265
  43. Chandrasekar B, Fernandes G. Decreased pro-inflammatory cytokines and increased antioxidant enzyme gene expression by omega-3 lipids in murine lupus nephritis. Biochem Biophys Res Commun. 1994;200:893
  44. Lee TH, Hoover RL, Williams JD, et al.  Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med. 1985;312:1217
  45. Fisher M, Levine PH, Weiner BH, et al.  Dietary n-3 fatty acid supplementation reduces superoxide production and chemiluminescence in monocyte-enriched preparation of leukocytes. Am J Clin Nutr. 1990;51:804
  46. Fisher M, Upchurch KS, Levine PH. Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential.. Inflammation. 1986;10:387
  47. Prasad K. Hydroxyl radical scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed. Mol Cell Biochem 1996;168:117.
  48. Bucolo D, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973;19:476
  49. Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:740
  50. Prasad K, Kalra J, Chaudhary AK, Debnath D. Effects of polymorphonuclear leukocyte-derived oxygen free radicals and hypochlorous acid on cardiac function and some biochemical parameters. Am Heart J. 1990;119:538
  51. Prasad K, Lee P, Kalra J. Influence of endothelin on cardiovascular function, oxygen free radicals, and blood chemistry. Am Heart J. 1992;121:178
  52. Holman RS, McGill HC, Strong JP, Greer JC. Techniques for studying atherosclerotic lesions. Lab Invest. 1958;7:42
  53. Ingram AJ, Parbtani A, Clark WF, et al.  Effects of flax-seed and flax oil diets in a rat-5/6 renal ablation model. Am J Kidney Dis. 1995;25:320
  54. Hall AV, Parbtani A, Clark WF, et al.  Abrogation of MRL/lpr lupus nephritis by dietary flax-seed. Am J Kidney Dis. 1993;22:326
  55. Clark WF, Parbtani A, Huff MW, et al.  Flax-seed: a potential treatment for lupus nephritis. Kidney Int. 1995;48:475
  56. Sugano M, Nakashima Y, Tasaki H, Takasugi M, Kuroiwa A, Koide O. Effects of diltiazem on suppression and regression of experimental atherosclerosis. Br J Exp Path. 1988;69:519
  57. Viswanathan NM, Bhakthan NMG, Rockerbie RA. Effect of dietary supplementation of vitamin E on serum lipids and lipoproteins in rabbit fed a cholesterolemic diet. Int J Vit Nutr Res. 1979;49:370
  58. Adelstein R, Ferguson LD, Rogers KA. Effects of dietary n-3 fatty acid supplementation on lipoproteins and intimal foam cell accumulation in casein-fed rabbit. Clin Invest Med. 1992;15:71
  59. Ratnayake WMN, Behrens WA, Fischer PWF, L'Abbe MR, Mongeau R, Beare Rodgers JL. Chemical and nutritional studies of flax-seed (Variety Linott) in rats. J Nutr Biochem. 1992;3:232
  60. Ross R. The pathogenesis of atherosclerosis—an update. N Engl J Med. 1986;314:488

PII: S0021-9150(97)06110-8

Atherosclerosis
Volume 132, Issue 1 , Pages 69-76 , 11 July 1997

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