Atherosclerosis
Volume 146, Issue 1 , Pages 107-115 , September 1999

Serum phospholipid transfer protein activity and genetic variation of the PLTP gene

  • Esa Tahvanainen

      Affiliations

    • Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    • Corresponding Author InformationCorresponding author. Tel.: +358-9-4744-8474; fax: +358-9-4744-8281
  • ,
  • Matti Jauhiainen

      Affiliations

    • Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
  • ,
  • Harald Funke

      Affiliations

    • Institut für Klinische Chemie und Laboratoriumsmedizin, University of Münster, Münster, Germany
  • ,
  • Erkki Vartiainen

      Affiliations

    • Department of Epidemiology, National Public Health Institute, Helsinki, Finland
  • ,
  • Jouko Sundvall

      Affiliations

    • Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
  • ,
  • Christian Ehnholm

      Affiliations

    • Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland

Received 29 September 1998 ,Revised 4 February 1999 ,Accepted 18 March 1999.

References 

  1. Barter PJ, Rye KA. Molecular mechanisms of reverse cholesterol transport. Curr Opin Lipidol. 1996;7:82–87
  2. Castro GR, Fielding CJ. Early incorporation of cell-derived cholesterol into pre-β-migrating high-density lipoprotein. Biochemistry. 1988;27:25–29
  3. Tollefson JH, Ravnik S, Albers JJ. Isolation and characterization of a phospholipid transfer protein (LTP-II) from human plasma. J Lipid Res. 1988;29:1593–1602
  4. Tall AR, Krumholz S, Olivecrona T, Deckelbaum RJ. Plasma phospholipid transfer protein enhances transfer and exchange of phospholipids between very low density lipoproteins and high density lipoproteins during lipolysis. J Lipid Res. 1985;26:842–851
  5. Rao R, Albers JJ, Wolfbauer G, Pownall HJ. Molecular and macromolecular specificity of human plasma phospholipid transfer protein. Biochemistry. 1997;36:3645–3653
  6. Jauhiainen M, Metso J, Pahlman R, Blomqvist S, van Tol A, Ehnholm C. Human plasma phospholipid transfer protein causes high density lipoprotein conversion. J Biol Chem. 1993;268:2032–2036
  7. Marques-Vidal P, Jauhiainen M, Metso J, Ehnholm C. Transformation of high density lipoprotein 2 particles by hepatic lipase and phospholipid transfer protein. Atherosclerosis. 1997;133:87–95
  8. Von Eckardstein A, Jauhiainen M, Huang Y, Metso J, Langer C, Pussinen P, et al. Phospholipid transfer protein-mediated conversion of high density lipoproteins (HDL) generates prebeta1-HDL. Biochim Biophys Acta. 1996;1301:255–262
  9. Mallow MJ, Zoppo A, Tu A-Y, O’Connor P, Kunitake ST, Hamilton RL, et al. A new metabolic disorder: phospholipid transfer protein deficiency. Clin Res. 1994;42:85;Abstract
  10. Day JR, Albers JJ, Lofton-Day CE, Gilbert TL, Ching AFT, Grant FJ, et al. Complete cDNA encoding human phospholipid transfer protein from human endothelial cells. J Biol Chem. 1994;269:9388–9391
  11. Whitmore TE, Day JR, Albers JJ. Localization of the human phospholipid transfer protein gene to chromosome 20q12-q13.1. Genomics. 1995;28:599–600
  12. Shimmoto M, Nakahori Y, Matsushita I, Shinka T, Kuroki Y, Itoh K, et al. A human protective protein gene partially overlaps the gene encoding phospholipid transfer protein on the complementary strand of DNA. Biochem Biophys Res Commun. 1996;220:802–806
  13. Tu AY, Deeb SS, Iwasaki L, Day JR, Albers JJ. Organization of human phospholipid transfer protein gene. Biochem Biophys Res Commun. 1995;207:552–558
  14. Lumb RH, Benson BJ, Clements JA. Transfer of phospholipids by a protein fraction obtained from canine pulmonary lavage. Biochim Biophys Acta. 1988;963:549–552
  15. Jiang XC, Bruce C. Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. J Biol Chem. 1995;270:17133–17138
  16. Albers JJ, Tu A-Y, Wolfbauer G, Cheung MC, Marcovina SM. Molecular biology of phospholipid transfer protein. Curr Opin Lipidol. 1996;7:88–93
  17. Albers JJ, Tu AY, Paigen B, Chen H, Cheung MC, Marcovina SM. Transgenic mice expressing human phospholipid transfer protein have increased HDL/non-HDL cholesterol ratio. Int J Clin Lab Res. 1996;26:262–267
  18. Xiang-chen J, Francone OL, Bruce C, Milne R, Mar J, Walsh A, et al. Increased pre-β-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes. J Clin Invest. 1996;98:2373–2380
  19. Föger B, Santamarina-Fojo S, Shamburek RD, Parrot CL, Talley GD, Brewer HB. Plasma phospholipid transfer protein-Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL. J Biol Chem. 1997;272:27393–27400
  20. Ehnholm S, van Dijk KW, van t’Hof B, van der Zee A, Olkkonen VM, Jauhiainen M, et al. Adenovirus mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice. J Lipid Res. 1998;39:1248–1253
  21. Vartiainen E, Puska P, Jousilahti P, Korhonen HJ, Tuomilehto J, Nissinen A. Twenty-year trends in coronary risk factors in North Karelia and in other areas of Finland. Int J Epidemiol. 1994;23:495–504
  22. Röschlau P, Bernt E, Gruber W. Enzymatische bestimmung des gesamt-cholesterins im serum. Z Clin Chem Biochem. 1974;12:403–407
  23. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  24. Damen J, Regts J, Scherphof G. Transfer of [14C]phosphatidylcholine between liposomes and human plasma high density lipoproteins. Partial purification of a transfer-stimulating plasma factor using a rapid transfer assay. Biochim Biophys Acta. 1982;712:444–452
  25. Tu A-Y, Wolfbauer G, Albers JJ. Functional characterization of the promoter region of the human phospholipid transfer protein gene. Biochem Biophys Res Commun. 1995;217:705–711
  26. Syvänen AC, Sajantila A, Lukka M. Identification of individuals by analysis of biallelic DNA markers, using PCR and solid-phase minisequencing. Am J Hum Genet. 1993;52:46–59
  27. Riggins GJ, Lokey LK, Chastain JL, Leiner HA, Sherman SL, Wilkinson KD, et al. Human genes containing polymorphic trinucleotide repeats. Nat Genet. 1992;2:186–191
  28. Rothschild CB, Akots G, Hayworth R, Pettenati MJ, Rao PN, Wood P, et al. A genetic map of chromosome 20q12-q13.1: Multiple highly polymorphic microsatellite and RFLP markers linked to the Maturity-Onset diabetes of the young (MODY) locus. Am J Hum Genet. 1993;52:110–123
  29. Slatkin M, Excoffier L. Testing for linkage disequilibrium in genotypic data using the EM algorithm. Heredity. 1996;76:377–383
  30. Schneider S., Kueffer J.-M., Roessli D., Excoffier L. Arlequin: a software package for population genetics. Genetics and Biometry Lab., Dept. of Anthropology, University of Geneva, 1996.
  31. Nikkilä E. Studies on the lipid–protein relationships in normal and pathologic sera and the effect of heparin on serum lipoproteins. Scand J Clin Lab Invest. 1953;5(Suppl 8):1–101
  32. Miller GJ, Miller NE. Plasma high-density-lipoprotein concentration and development of ischaemic heart disease. Lancet. 1975;1:16–19
  33. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoproteins as a protective factor against coronary heart disease. The Framingham study. Am J Med. 1977;62:707–714
  34. Rubin EM, Ishida BY, Clift SM, Kraus RM. Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and appearance of two new high density lipoprotein size subclasses. Proc Natl Acad Sci USA. 1991;88:434–438
  35. Fielding CJ, Fielding PE. Molecular physiology of reverse cholesterol transport. J Lipid Res. 1995;36:211–228
  36. Lagrost L, Desrumaux C, Masson D, Deckert V, Gambert P. Structure and function of the plasma phospholipid transfer protein. Curr Opin Lipidol. 1998;9:203–209
  37. Rye K-A, Jauhiainen M, Barter PJ, Ehnholm C. Triglyceride-enrichment of high density lipoproteins enhances their remodelling by phospholipid transfer protein. J Lipid Res. 1998;39:613–622
  38. Dullaart RP, Sluiter WJ, Dikkeschei LD, Hoogenberg K, Van Tol A. Effect of adiposity on plasma lipid transfer protein activities: a possible link between insulin resistance and high density lipoprotein metabolism. Eur J Clin Invest. 1994;24:188–194
  39. Mero N, Van Tol A, Scheek LM, Van Gent T, Labeur C, Rosseneu M, et al. Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: relations with lipid transfer proteins and LCAT activities. J Lipid Res. 1998;39:1493–1502
  40. Lagrost L, Athias A, Herbeth B, Guyard-Dangremont V, Artur Y, Paille F, et al. Opposite effects of cholesteryl ester transfer protein and phospholipid transfer protein on the size distribution of plasma high density lipoproteins. Physiological relevance in alcoholic patients. J Biol Chem. 1996;271:19058–19065
  41. Pussinen PJ, Jauhiainen M, Ehnholm C. ApoA-II/apoA-I molar ratio in the HDL particle influences phospholipid transfer protein-mediated HDL interconversion. J Lipid Res. 1997;38:12–21
  42. Wong L, Curtiss LK, Huang J, Mann CJ, Maldonado B, Roheim PS. Altered epitope expression of human interstitial fluid apolipoprotein A-I reduces its ability to activate lecitin cholesterol acyl transferase. J Clin Invest. 1992;90:2370–2375
  43. Sloop CH, Dory L, Hamilton RL, Krause BR, Roheim PS. Characterization of dog peripheral lymph lipoproteins: the presence of a disc-shaped ‘nascent’ high density lipoprotein. J Lipid Res. 1983;24:1429–1440
  44. Lagrost L, Athias A, Gambert P, Lallemant C. Comparative study of phospholipid transfer activities mediated by cholesteryl ester transfer protein and phospholipid transfer protein. J Lipid Res. 1994;35:825–835
  45. van Tol A, Ligtenberg JJM, Riemens SC, van Haeften TW, Reitsma WD, Dullaart RPF. Lowering of plasma phospholipid transfer protein activity by acute hyperglycaemia-induced hyperinsulinemia in healthy men. J Clin Lab Invest. 1994;57:147–158

PII: S0021-9150(99)00140-9

Atherosclerosis
Volume 146, Issue 1 , Pages 107-115 , September 1999