Atherosclerosis
Volume 148, Issue 1 , Pages 141-149, January 2000

Low density lipoprotein particle size and risk factors of insulin resistance syndrome

  • Yechiel Friedlander

      Affiliations

    • The Department of Social Medicine, The Hebrew University-Hadassah School of Public Health, POB 12272, Jerusalem 91120, Israel
    • Corresponding Author InformationCorresponding author. Tel.: +972-2-677-7115; fax: +972-2-643-1086
    • ,
  • Miriam Kidron

      Affiliations

    • The Diabetes Unit, Division of Medicine, The Hadassah University Hospital, Jerusalem, Israel
    • ,
  • Muriel Caslake

      Affiliations

    • The Department of Pathological Biochemistry, The University of Glasgow, Glasgow, Scotland, UK
    • ,
  • Tracey Lamb

      Affiliations

    • The Department of Pathological Biochemistry, The University of Glasgow, Glasgow, Scotland, UK
    • ,
  • Michael McConnell

      Affiliations

    • The Department of Pathological Biochemistry, The University of Glasgow, Glasgow, Scotland, UK
    • ,
  • Hanoch Bar-On

      Affiliations

    • The Diabetes Unit, Division of Medicine, The Hadassah University Hospital, Jerusalem, Israel

Received 26 February 1999; received in revised form 7 May 1999; accepted 2 June 1999. published online 16 August 2004.

Abstract 

The present study aimed to examine the association between low density lipoprotein (LDL) particle size and glucose and insulin variables and with other risk factors that have been related to insulin resistance syndrome. LDL particle size was determined in two groups of subjects who participated in the first examination of the Jerusalem Diabetes Study and who were invited to be re-examined after 8–10 years. The first group were non-diabetic subjects who were found to have at the first examination high insulin levels (above the sex and age specific 90th percentile of the 2 h post-glucose load insulin distribution). The second group was a random sample of individuals who had normal insulin and glucose levels at baseline. Sex-, Age- and body mass index (BMI) mean adjusted LDL-cholesterol (C), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) levels were significantly different among the LDL subclass groups. Fasting glucose levels and hemoglobin A1c did not differ statistically by LDL subclasses. Fasting and 2-h post load insulin levels were significantly higher in persons with LDL subclasses III and IV (small LDL), intermediate in those with LDL subclass II, and lowest in those with LDL subclass I (large LDL). Insulin resistance had an effect on the association between lipids, lipoproteins and LDL particle size. Multivariate analyses indicated that LDL-C, HDL-C and TG were independently associated with LDL particle size variability. The addition of ‘insulin resistance’ or insulin and glucose levels had no independent effects on LDL particle size. In conclusion, an association of LDL particle size with the cluster of risk factors that characterize the insulin resistance syndrome has been demonstrated. The association of ‘insulin resistance’ and LDL particle diameter, however, is not mediated directly through the level of insulinemia but via alterations in lipid metabolism.

Keywords:  LDL subclass, Insulin resistance, Lipids, Lipoproteins

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PII: S0021-9150(99)00215-4

Atherosclerosis
Volume 148, Issue 1 , Pages 141-149, January 2000

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