Atherosclerosis
Volume 148, Issue 1 , Pages 151-158 , January 2000

Lipoprotein correlates of LDL particle size

Received 19 February 1999 ,Revised 29 April 1999 ,Accepted 2 June 1999.

References 

  1. Austin MA, King M-C, Vranizan KM, Krauss RM. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation. 1990;82:495–506
  2. Gardner CD, Fortmann SP, Krauss RM. Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women. JAMA. 1996;276:875–881
  3. Stampfer MJ, Krauss RM, Ma J, et al.  A prospective study of triglyceride level, low-density lipoprotein particle diameter and risk of myocardial infarction. JAMA. 1996;276:882–888
  4. Lamarche B, Tchernof A, Moorjani S, et al.  Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Circulation. 1997;95:69–75
  5. Austin MA. Genetic epidemiology of dyslipidaemia and atherosclerosis. Ann Med. 1996;28:459–463
  6. Hurt-Camejo E, Olsson U, Wiklund O, Bondjers G, Camejo G. Cellular consequences of the association of apoB lipoproteins with proteoglycans. Potential contribution to atherogenesis. Arterioscler Thromb Vasc Biol. 1997;17:1011–1017
  7. Galeano NF, Al-Haideri M, Keyserman F, Rumsey SC, Deckelbaum RJ. Small dense low density lipoprotein has increased affinity for LDL receptor-independent cell surface binding sites: a potential mechanism for increased atherogenicity. J Lipid Res. 1998;39:1263–1273
  8. McNamara JR, Campos H, Ordovas JM, Peterson J, Wilson PWF, Schaefer EJ. Effect of gender, age, and lipid status on low density lipoprotein subfraction distribution. Arteriosclerosis. 1987;7:483–490
  9. Tchernof A, Lamarche B, Prud’homme D, et al.  The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care. 1996;19:629–637
  10. Mitchell BD, Kammerer CM, Blangero J, et al.  Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study. Circulation. 1996;94:2159–2170
  11. Cheng M-L, Woodford SC, Hilburn JL, VandeBerg JL. A novel system for storage of sera frozen in small aliquots. J Biochem Biophys Methods. 1986;13:47–51
  12. Warnick GR, Benderson J, Albers JJ. Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin Chem. 1982;28:1379–1388
  13. Demacker PN, Hijmans AG, Brenninkmeijer BJ, Jansen AP, Van't Laar A. Five methods for determining low-density lipoprotein cholesterol compared. Clin Chem. 1984;30:1797–1800
  14. Demacker PNM, Toenhake-Dijkstra H, de Rijke YB, Stalenhoef AFH, Stuyt PMJ, Willems HL. On the presumed inaccuracy of the Friedewald formula in hypertriglyceridemic plasma: a role for imprecise analysis?. Clin Chem. 1996;42:1491–1494
  15. Singh ATK, Rainwater DL, Haffner SM, et al.  Effect of diabetes on lipoprotein size. Arterioscler Thromb Vasc Biol. 1995;15:1805–1811
  16. Rainwater DL. Electrophoretic separation of LDL and HDL subclasses. Methods Mol Biol 1998; 110:137–151.
  17. Rainwater DL, Andres DW, Ford AL, Lowe WF, Blanche PJ, Krauss RM. Production of polyacrylamide gradient gels for the electrophoretic resolution of lipoproteins. J Lipid Res. 1992;33:1876–1881
  18. Cheng M-L, Kammerer CM, Lowe WF, Dyke B, VandeBerg JL. Method for quantitating cholesterol in subfractions of serum lipoproteins separated by gradient gel electrophoresis. Biochem Genet. 1988;26:657–681
  19. Rainwater DL, Blangero J, Hixson JE, Birnbaum S, Mott GE, VandeBerg JL. A DNA polymorphism for LCAT is associated with altered LCAT activity and high density lipoprotein size distributions in baboons. Arterioscler Thromb. 1992;12:682–690
  20. Rainwater DL, Blangero J, Moore PH, Shelledy WR, Dyer TD. Genetic control of apolipoprotein A-I distribution among HDL subclasses. Atherosclerosis. 1995;118:307–317
  21. World Health Organization Diabetes Mellitus: Report of a WHO Study Group. WHO Tech Rep Ser 1985;727:1–113.
  22. Austin MA, Jarvik GP, Hokanson JE, Edwards K. Complex segregation analysis of LDL peak particle diameter. Genet Epidemiol. 1993;10:599–604
  23. Rotter JI, Bu X, Cantor RM, et al.  Multilocus genetic determinants of LDL particle size in coronary artery disease families. Am J Hum Genet. 1996;58:585–594
  24. Austin MA, Mykkanen L, Kuusisto J, et al.  Prospective study of small LDLs as a risk factor for non-insulin dependent diabetes mellitus in elderly men and women. Circulation. 1995;92:1770–1778
  25. Tribble DL, Holl LG, Wood PD, Krauss RM. Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing density and particle size. Atherosclerosis. 1992;93:189–199
  26. Williams PT, Krauss RM, Vranizan KM, Stefanick ML, Wood PDS, Lindgren FT. Associations of lipoproteins and apolipoproteins with gradient gel electrophoresis estimates of high density lipoprotein subfractions in men and women. Arterioscler Thromb. 1992;12:332–340
  27. Katzel LI, Krauss RM, Goldberg AP. Relations of plasma TG and HDL-C concentrations to body composition and plasma insulin levels are altered in men with small LDL particles. Arterioscler Thromb. 1994;14:1121–1128
  28. Rainwater DL, Ludwig MJ, Haffner SM, VandeBerg JL. Lipid and lipoprotein factors associated with variation in Lp(a) density. Arterioscler Thromb Vasc Biol. 1995;15:313–319
  29. Ohta T, Saku K, Takata K, Nagata N, Maung KK, Matsuda I. Fractional esterification rate of cholesterol in high density lipoprotein (HDL) can predict the particle size of low density lipoprotein and HDL in patients with coronary heart disease. Atherosclerosis. 1997;135:205–212
  30. Campos H, Bailey SM, Gussak LS, Siles X, Ordovas JM, Schaefer EJ. Relations of body habitus, fitness level, and cardiovascular risk factors including lipoproteins and apolipoproteins in a rural and urban Costa Rican population. Arterioscler Thromb. 1991;11:1077–1088
  31. Feingold KR, Grunfeld C, Pang M, Doerrler W, Krauss RM. LDL subclass phenotypes and triglyceride metabolism in non- insulin-dependent diabetes. Arterioscler Thromb. 1992;12:1496–1502
  32. Selby JV, Austin MA, Newman B, et al.  LDL subclass phenotypes and the insulin resistance syndrome in women. Circulation. 1993;88:381–387
  33. Haffner SM, Mykkänen L, Stern MP, Paidi M, Howard BV. Greater effect of diabetes on LDL size in women than in men. Diabetes Care. 1994;17:1164–1171
  34. Austin MA, Selby JV. LDL subclass phenotypes and the risk factors of the insulin resistance syndrome, Int J Obesity, 1995;19 Suppl. (1): S22–S26.
  35. Haffner SM, Mykkänen L, Robbins D, et al.  A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects. Diabetologia. 1995;38:1328–1336
  36. Suehiro T, Ohguro T, Sumiyoshi R, et al.  Relationship of low-density lipoprotein particle size to plasma lipoproteins, obesity, and insulin resistance in Japanese men. Diabetes Care. 1995;18:333–338
  37. Lamon-Fava S, Wilson PWF, Schaefer EJ. Impact of body mass index on coronary heart disease risk factors in men and women. The Framingham Offspring Study. Arterioscler Thromb Vasc Biol. 1996;16:1509–1515
  38. Gray RS, Robbins DC, Wang W, et al.  Relation of LDL size to the insulin resistance syndrome and coronary heart disease in American Indians — The Strong Heart Study. Arterioscler Thromb Vasc Biol. 1997;17:2713–2720
  39. Mykkänen L, Haffner SM, Rainwater DL, Karhapää P, Miettinen H, Laakso M. Relationship of LDL size to insulin sensitivity in normoglycemic men. Arterioscler Thromb Vasc Biol. 1997;17:1447–1453
  40. Williams PT, Krauss RM. Associations of age, adiposity, menopause, and alcohol intake with low-density lipoprotein subclasses. Arterioscler Thromb Vasc Biol. 1997;17:1082–1090
  41. Capell WH, Zambon A, Austin MA, Brunzell JD, Hokanson JE. Compositional differences of LDL particles in normal subjects with LDL subclass phenotype A and LDL subclass phenotype B. Arterioscler Thromb Vasc Biol. 1996;16:1040–1046
  42. McNamara JR, Small DM, Li Z, Schaefer EJ. Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B. J Lipid Res. 1996;37:1924–1935

PII: S0021-9150(99)00216-6

Atherosclerosis
Volume 148, Issue 1 , Pages 151-158 , January 2000

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