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Abstract
Free radical (FR) mediated oxidation of low density lipoproteins (LDL) has been implicated
in atherogenesis. Probucol is a lipid lowering agent with antioxidant properties which
may protect the LDL from FR mediated damage. The specific mechanism by which probucol
acts as an antioxidant has not previously been reported. We therefore studied the
FR scavenging properties of probucol in vitro and results show that this drug is a
powerful superoxide scavenger. This property may be relevant in its use as a lipid
lowering drug in the retardation of the atherosclerotic process.
Keywords
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References
- The pathogenesis of atherosclerosis: atherogenesis and inflammation.Lab. Invest. 1988; 58: 249
- Antiatherogenic effect of probucol unrelated to its hypocholesterolaemic effect.in: Proc. Natl. Acad. Sci. USA. 84. 1987: 7725
- Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit: an animal model for familial hypercholesterolemia.in: Proc. Natl. Acad. Sci. USA. 84. 1987: 5928
- Superoxide dismutase; a photochemical augmentation assay.Arch. Biochem., Biophys. 1977; 187: 303
- Effect of probucol treatment on lipoprotein cholesterol and drug levels in blood and lipoproteins in familial hypercholesterolaemia.Atherosclerosis. 1986; 59: 47
- Plasma levels of probucol in man after single and repeated oral doses.Nouv. Presse Med. 1980; 9: 2990
- LDL induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cell in culture.Atherosclerosis. 1979; 32: 213
- Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.in: Proc. Natl. Acad. Sci. USA. 84. 1987: 2995
- Endothelial cell derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein.in: Proc. Natl. Acad. Sci. USA. 82. 1985: 5949
- Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition.in: Proc. Natl. Acad. Sci. USA. 76. 1979: 333
- Probucol inhibits oxidation modification of low density lipoproteins.J. Clin. Invest. 1986; 77: 641
- The effect of diet on the transport of probucol in monkeys.Artery. 1982; 10: 105
Article Info
Publication History
Accepted:
May 20,
1991
Received in revised form:
May 10,
1991
Received:
January 25,
1991
Identification
Copyright
© 1991 Published by Elsevier Inc.
