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Abstract
The effect on serum lipids of oral administration of 2 g calcium daily during 8 weeks
was studied in 16 Hyperlipidemic patients. The study was preceded by a 4 week placebo
period. Five patients were classified as having type IIA hyperlipidemia according
to Fredrickson et al. (as modified), 10 patients as having type IIB and 1 patient as having type IV. Body
weight before the study and mean values during placebo and calcium therapy were 70.2
± 2.49 kg, 70.0 ± 2.54 kg and 69.4 ± 2.55 kg respectively. The difference between
placebo mean value and calcium mean value was significant at the 5% level.
The average serum triglyceride value before treatment was 2.89 ± 0.383 mmol/1, during
treatment with placebo 2.45 ± 0.266 mmol/l and during calcium treatment 2.70 ± 0.286
mmol/l. The decrease during placebo therapy when compared to the mean value before
treatment was significant at the 5% level. No decrease in serum triglycerides could
be ascribed to calcium therapy. The average serum cholesterol value before treatment
was 337 ± 13.5 mg/ 100 ml and decreased to 321 ± 12.8 mg/ 100 ml during placebo treatment
and to 303 ± 12.0 mg/ 100 ml during treatment with calcium. The decrease was significant
at the 1% level when the mean value before treatment was compared to the average value
during placebo therapy, and was significant at the 0.1% level when the mean value
during placebo treatment was compared to the mean value during calcium therapy. No
correlation was noted between either total or low density lipoprotein cholesterol
levels before treatment and decrease in total cholesterol levels.
Keywords
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Article info
Publication history
Received:
May 14,
1971
Footnotes
☆This work was supported by grants from Nationalföreningen mot Hjärt-och Lungsjukdomar.
Identification
Copyright
© 1971 Published by Elsevier Inc.
