Experimental arteriosclerosis in dogs

Evaluation of anatomopathological findings
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      Young adult dogs fed a cholesterol supplemented semi-synthetic diet containing hydrogenated coconut oil without thiouracil for periods of 16 weeks to 16 months were studied in order to identify early vascular lesions as well as overt arteriosclerosis.
      In 16 weeks, ultrastructural medial cell changes were present in the abdominal aorta of all animals, while the same diet without cholesterol supplement failed to induce lesions.
      Arteriosclerotic lesions in the long-term study were characterized by extensive intra and extracellular lipid deposits in smooth muscle cells of the arterial media and to much less extent, of the intimal lining. These changes were usually more severe in small peripheral arteries than in the thoracic aorta or the coronary vessels. Although segmental stenotic lesions were common in severely involved vessels, thrombosis or infarction were not usual complications of advanced arterial disease.


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