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Abstract
Young adult dogs fed a cholesterol supplemented semi-synthetic diet containing hydrogenated
coconut oil without thiouracil for periods of 16 weeks to 16 months were studied in
order to identify early vascular lesions as well as overt arteriosclerosis.
In 16 weeks, ultrastructural medial cell changes were present in the abdominal aorta
of all animals, while the same diet without cholesterol supplement failed to induce
lesions.
Arteriosclerotic lesions in the long-term study were characterized by extensive intra
and extracellular lipid deposits in smooth muscle cells of the arterial media and
to much less extent, of the intimal lining. These changes were usually more severe
in small peripheral arteries than in the thoracic aorta or the coronary vessels. Although
segmental stenotic lesions were common in severely involved vessels, thrombosis or
infarction were not usual complications of advanced arterial disease.
Keywords
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References
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Mälmros, H., Personal communication.
Article info
Publication history
Received:
July 12,
1971
Footnotes
☆This study was supported in part by grant HE-6835 from the National Heart and Lung Institute.
☆Although the terms arteriosclerosis and atherosclerosis are often used interchangeably, the former is preferred as a generic term in this report for experimental lesions that do not fulfill all criteria of the partial definition for atherosclerosis proposed by W. H. O. study group, London, 1957.
Identification
Copyright
© 1972 Published by Elsevier Inc.
