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Plasma proteins, oxygen transport and atherosclerosis

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      Abstract

      In summary, we have presented evidence to support the hypoxic theory for the formation of atherosclerosis. More importantly, though, we have presented the following etiology for such hypoxia:
      • 1.
        (1) Oxygen transport is affected by plasma protein concentrations and in most humans probably decreases with age;
      • 2.
        (2) The result of hypoxia at the aortic lining is a degeneration of surface features which results in increased cellular permeability; and
      • 3.
        (3) The interior structure of the vessel is further disorganized due to the influx of lipids and other plasmatic matter. This in turn accelerates oxygen demand and augments hypoxia.
      These ideas concerning the effects of proteins on oxygen transport, as well as the importance of the diffusion resistance of blood plasma, provide strong indications of a comprehensive mechanism for the occurrence of atherosclerosis and other vascular changes associated with aging.

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      References

        • Hueper W.C.
        Arteriosclerosis. The anoxemia theory.
        Arch. Pathol. 1944; 39: 162
        • Hueper W.C.
        Arteriosclerosis. The anoxemia theory.
        Arch. Pathol. 1944; 39: 245
        • Hueper W.C.
        Arteriosclerosis. The anoxemia theory.
        Arch. Pathol. 1944; 39: 350
        • Büchner F.
        • Luft U.
        Hypoxämische Veränderungen des Zentralnervensystems im Experiment.
        Beitr. Pathol. Anat. Allg. Pathol. 1936; 96: 549
        • Thorner M.W.
        • Lewy F.H.
        The effects of repeated anoxia on the brain.
        J. Amer. Med. Ass. 1940; 115: 1595
        • Campbell J.A.
        Prolonged alterations of oxygen pressure in inspired air with special reference to tissue oxygen tension, tissue carbon dioxide tension and haemoglobin.
        J. Physiol. (London). 1926; 62: 211
        • Kjeldsen K.
        • Wanstrup J.
        • Astrup P.
        Enhancing influence of arterial hypoxia on the development of atheromatosis in cholesterol-fed rabbits.
        J. Atheroscler. Res. 1968; 8: 835
        • Kipshidge N.N.
        The effect of oxygen deficiency on the development of experimental atherosclerosis of the coronary arteries.
        Bull. Exp. Biol. Med. 1959; 47: 54
        • Astrup P.
        • Kjeldsen K.
        • Wanstrup J.
        The effects of exposure to carbon monoxide, hypoxia and hyperoxia on the development of experimental atheromatosis in rabbits.
        in: Jones R.J. Atherosclerosis (Proceedings of the 2nd International Symposium). Springer, New York1970: 108
        • Helin P.
        • Lorenzen I.
        • Garbarsch C.
        • Matthiessen M.E.
        Arteriosclerosis and hypoxia, Part 2 (Biochemical changes in mucopolysaccharides and collagen of rabbit aorta induced by systemic hypoxia).
        J. Atheroscler. Res. 1969; 9: 295
        • Helin P.
        • Lorenzen I.
        Arteriosclerosis in rabbit aorta induced by systemic hypoxia.
        Angiology. 1969; 20: 1
        • Garbarsch C.
        • Mathiessen M.E.
        • Helin P.
        • Lorenzen I.
        Arteriosclerosis and hypoxia, Part 1 (Gross and microscopic changes in rabbit aorta, induced by systemic hypoxia, Histochemical studies).
        J. Atheroscler. Res. 1969; 9: 283
        • Constantinides P.
        The role of endothelial injury in arterial thrombosis and atherogenesis.
        Advan. Cardiol. 1970; 4: 67
        • Astrup P.
        • Kjeldsen K.
        • Wanstrup J.
        Enhancing influence of carbon monoxide on the development of atheromatosis in cholesterol-fed rabbits.
        J. Atheroscler. Res. 1967; 7: 343
        • Wanstrup J.
        • Kjeldsen K.
        • Astrup P.
        Acceleration of spontaneous intimal-subintimal changes in rabbit aorta by a prolonged moderate carbon monoxide exposure.
        Acta Pathol. Microbiol. Scand. 1969; 75: 353
        • Wanstrup J.
        • Kjeldsen
        • Astrup P.
        Reversal of rabbit atheromatosis by hyperoxia.
        J. Atheroscler. Res. 1969; 10: 173
        • Altschul R.
        • Herman I.H.
        Influence of oxygen inhalation on cholesterol metabolism.
        Arch. Biochem. Biophys. 1954; 51: 308
        • Dixon K.C.
        Deposition of globular lipid in arterial cells in relation to anoxia.
        Amer. J. Pathol. 1961; 39: 65
        • Woener C.A.
        Vasa vasorum of arteries, their demonstration and distribution.
        in: Lansing A.I. The Arterial Wall. Williams and Wilkins, Baltimore, Md1959: 1
        • Kirk J.E.
        • Laursen T.J.S.
        Diffusion coefficients of various solutes for human aortic tissue with special reference to variation in tissue permeability with age.
        J. Gerontol. 1955; 10: 288
        • Lazzarini-Robertson Jr., A.
        Oxygen requirements of the human arterial intima in atherogenesis.
        Progr. Biochem. Pharmacol. 1968; 4: 305
        • Bredt H.
        Morphology.
        in: Schettler F.G. Boyd G.S. Atherosclerosis. Elsevier, Amsterdam1969 (Ch. 1)
        • Metzner A.B.
        Diffusive transport rates in structured media.
        Nature (London). 1965; 208: 267
        • Navari R.M.
        Mass Transfer in Biological Systems.
        in: 6th edition. Ph.D. Dissertation. University of Virginia, Charlottesville, Va1970
        • Navari R.M.
        • Gainer J.L.
        • Hall K.R.
        Effect of plasma constituents on oxygen diffusivity.
        in: Hershey D. Blood Oxygenation. Plenum Press, New York1970: 243
        • Chisolm G.M.
        • Terrado E.N.
        • Gainer J.L.
        Physiological transport in relation to aging.
        Nature (London). 1971; 230: 390
        • Sunago T.
        • Yamashita Y.
        • Numano F.
        • Shimamoto T.
        Luminal surface of normal and atherosclerotic arteries observed by scanning electron microscope.
        in: Scanning Electron Microscopy/1970. I.I.T. Research Institute, Chicago, Ill1970: 241
        • Sinha A.K.
        Oxygen Uptake and Release by Red Cells through Capillary Wall and Plasma Layer.
        in: 6th edition. Ph.D. Dissertation. University of California, San Francisco, Calif1969
        • Gutstein W.H.
        • Schneck D.J.
        • Marks J.O.
        In vitro studies of local blood flow disturbance in a region of separation.
        J. Atheroscler. Res. 1968; 8: 381
        • Tarnay T.J.
        Arterial embolism of the extremities.
        Arch. Surg. 1969; 99: 615
        • Cochrane C.G.
        • Hawkins D.
        • Kniker W.T.
        Mechanisms involved in the localization of circulating immune complexes in blood vessels.
        in: Miescher P. Grabar P. Immunopathology (5th International Symposium). Grune and Stratton, New York, N.Y1967: 32
        • Abramoff P.
        • La Via M.
        Biology of the Immune Response.
        McGraw-Hill, New York, N.Y1970
        • Movat H.Z.
        • Fernando N.V.P.
        Allergic inflammation, Part I (The earliest fine structural changes at the blood-tissue barrier during antigen-antibody interaction).
        Amer. J. Pathol. 1963; 42: 41