Research paper| Volume 15, ISSUE 3, P349-357, May 1972

Changes of the mitral echocardiogram with ageing and the influence of atherosclerotic risk factors

  • U. Derman
    Address for reprints: Doçent Dr. Ugur Derman, Tedavi Kliniǧi, Haseki Hastahanesi, Aksaray, Istanbul, Turkey.
    The Second Internal Medicine Clinic, Cerrahpaşa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
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      With ageing slowing of mitral valve closure during early diastole, and low amplitude in the echocardiograms were observed, which simulate findings of mitral stenosis. These changes appear at an earlier age among patients carrying atherosclerotic risk factors such as diabetes, hypertension, or hypercholesterolaemia. Prominent “A” waves of the atrial systole were suggested as criteria for differentiating the echograms of these subjects, from those with mitral stenosis.


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        • Effert R.
        • Domanig E.
        Diagnostik intraaurikulärer Tumoren und grosser Thromben mit dem Ultraschall-echoverfahren.
        Dtsch. Med. Wochschr. 1959; 84: 6
        • Joyner C.R.
        • Reid J.M.
        Applications of ultrasound in cardiology and cardiovascular physiology.
        Progr. Cardiovasc. Dis. 1963; 5: 482
        • Effert S.
        • Domanig E.
        • Erkens H.
        Möglichkeiten des Ultraschall-echoverfahrens in der Herzdiagnostik.
        Cardiologia. 1959; 34: 73
        • Elder I.
        The diagnostic use of ultrasound in heart diseases.
        Acta Med. Scand. 1955; : 32
        • Segal B.L.
        Cardiologia. 1967; 50: 160
        • Ultan B.L.
        • Segal B.L.
        • Likoff W.
        Echocardiography in congenital heart disease.
        Amer. J. Cardiol. 1967; 19: 74
        • Rosenthal J.
        • Feigin I.
        Pathology of the mitral valve in the older age groups.
        Amer. Heart J. 1947; 33: 346
        • Sell S.
        • Scully R.E.
        Aging changes in the aortic and mitral valves.
        Amer. J. Pathol. 1965; 46: 345
        • Pomerance A.
        Pathogenesis of “senile” nodular sclerosis of atrioventricular valves.
        Brit. Heart J. 1966; 38: 815
        • Ashworth C.T.
        Atherosclerotic valvular disease of the heart.
        Arch. Pathol. 1946; 42: 285
      1. Gustafson, A., Ultrasoundcardiography in mitral stenosis. Acta Med. Scand., Suppl. 461.

        • Segal B.L.
        • Likoff W.
        • Kingsley B.
        Echocardiography in combined mitral stenosis and regurgitation.
        Amer. J. Cardiol. 1967; 19: 42
        • Pomerance A.
        Ageing changes in the human heart valves.
        Brit. Heart J. 1967; 29: 222
        • Pomerance A.
        Pathology of the heart with or without failure in the aged.
        Brit. Heart J. 1965; 27: 697
        • Hellwig C.A.
        Atheromatosis of the mitral valve.
        Amer. Heart J. 1942; 24: 41
        • McManus J.F.A.
        • Lupton C.H.
        Lipid deposits in the aortic cusp of the mitral valve. Their relationships to atheroma and atherosclerosis.
        Arch. Pathol. 1963; 75: 674
        • Moss A.J.
        Ballistocardiographic evaluation of the cardiovascular ageing process.
        Circulation. 1961; 23: 434
        • Scarborough W.L.
        • Mason R.E.
        • Davis F.W.
        • Singewald M.L.
        • Baker B.M.
        • Lore S.A.
        A ballistocardiographic and electrocardiographic study of 328 patients with coronary artery disease. Comparison with results from a similar study of apparently normal persons.
        Amer. Heart J. 1952; 44: 645
        • Baker B.M.
        Ballistocardiography. Predictor of coronary heart disease.
        Circulation. 1968; 37: 1
        • Benchimol A.
        • Dimond E.G.
        The apexcardiogram in ischaemic heart disease.
        Brit. Heart J. 1962; 24: 581
        • Benchimol A.
        • Dimond E.G.
        The apexcardiogram in normal older subjects and in patients with atherosclerotic heart disease. Effect of exercise on the “a” wave.
        Amer. Heart J. 1963; 65: 789