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Abstract
Atherosclerotic rabbit aortas incorporate more [2-14C]glucose into lipids when incubated under hypoxic than aerobic conditions. This increase
results from greater radiosubstrate incorporation into the glycerol moiety of glycerides
and phospholipids. Fatty acids are synthesized mainly by elongation; synthesis of
all fatty acids is less during hypoxia. Though the total amount of [1-14C]acetate incorporated into lipids is the same during both incubation conditions,
there is a redistribution so that this substrate equilibrates more into phospholipid
glycerol during hypoxia. Fatty acid synthesis from [1-14C]acetate is primarily by elongation and decreases during hypoxic incubation.
Keywords
Abbreviations:
TLC (thin-layer chromatography), GLC (gas-liquid chromatography)To read this article in full you will need to make a payment
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Article info
Publication history
Received:
August 12,
1971
Footnotes
☆This work was supported by the National Institutes of Health, U.S.P.H.S. grants No. AM-12601 (C.F.H.), No. HE-09744 (Dr. O. W. Portman), and FR-00163 (Oregon Regional Primate Research Center).
☆☆Publication No. 554 from the Oregon Regional Primate Research Center.
Identification
Copyright
© 1972 Published by Elsevier Inc.