Role of lipophages in the development of rat atheroma

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      Aortic specimens from rats maintained on an atherogenic diet were examined electron-microscopically for the role of lipophages in the evolution of atheroma, with special reference to the mode of migration of these cells into the vessel wall. Lipophages were found to enter the vessel wall actively by pushing apart the endothelial cells, and to settle in the subendothelial space where they helped to form the arterio-sclerotic changes. On the basis of ultrastructural characteristics, these lipophages were distinguishable from foam cells which arose from endothelial cells.


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