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Abstract
In short-term experiments in cockerels, elevation of plasma cholesterol from threshold
to excessively high levels induces coronary atherosclerosis in a curvilinear fashion
with the largest effect occurring in the lower ranges (from 100–500 mg/100 ml). Similar
increments of plasma cholesterol have a progressively smaller effect on coronary atherosclerosis
as the plasma cholesterol levels become higher. However, the results of long-term
experiments may differ from the short-term ones used in these experiments.
These experiments have a possible bearing on the efficacy of hypocholesterolemic procedures
clinically.
The nomogram established in this report can serve in this species (and at this age
and over this duration of the experiment) to distinguish coronary atherogenesis dependent
on hypercholesterolemia (per se) from that produced independently by the agent or
procedure employed.
Keywords
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References
- Effects of dietary protein and carbohydrate level on cholesterolemia and atherogenesis in cockerels on a high-fat, high-cholesterol mash.Circular. Res. 1958; 6: 447-451
- Serum cholesterol levels in human atherosclerosis.Canad. Med. Ass. J. 1960; 82: 6-11
- Natural history of human atherosclerotic lesions.in: Sandler M. Bourne G.H. Atherosclerosis and Its Origin. Academic Press, New York1963: 39
- A revision of the Schoenheimer-Sperry method for cholesterol determination.J. Biol. Chem. 1950; 187: 97-106
- Nutrition and Atherosclerosis.Lea and Febiger, Philadelphia1958
- Statistical Methods.in: The Iowa State University Press, Ames, Iowa1957: 450
- Roberts Jr., J.C. Straus R. Comparative Atherosclerosis. Harper and Row, Hoeber Medical Division, New York1965
- The age factor in hypercholesteremia and atheromatosis in the chick.Circulation. 1951; 3: 867-874
- Developmental patterns of coronary and aortic atherosclerosis in young Negroes of Haiti and the United States.Ann. Intern. Med. 1964; 61: 900-913
- Atherosclerosis in persons with coronary heart disease.Lab. Invest. 1968; 18: 527-537
- Epidemiology of cardiovascular mortality-geographic and ethnic.Amer. J. Publ. Hlth. 1962; 52: 94-105
- Lectures on Preventive Cardiology.in: Grune and Stratton, New York1967: 62-94 (Chapter 5)
- Serum lipid levels in normal persons: Findings of a cooperative study of lipoproteins and atherosclerosis.Circulation. 1957; 16: 227-245
- Cholesterol and beta lipoproteins in the serum of Americans-well persons and those with coronary heart disease.Amer. J. Med. 1957; 22: 605-623
- Coronary heart disease: Identification of susceptible individuals.in: Brest A.N. Moyer J.H. Atherosclerotic Vascular Disease. Appleton-Century-Crofts, New York1967
- The coronary profiles: 12 year followup in the Framingham study.J. Occup. Med. 1967; 9: 611-619
- Serum lipids as predictors of atherosclerotic disease.in: Brest A.N. Moyer J.H. Atherosclerotic Vascular Disease. Appleton-Century-Crofts, New York1967: 207-227 (Chapter 17)
Article info
Publication history
Received:
February 17,
1971
Footnotes
☆This work was supported by the National Heart Institute, Grant No. HE-06375 of the National Institute of Health, USPHS and the Chicago and American Heart Associations.
☆Some of this work was presented at the Federation of American Society for Experimental Biology, April 16–21, 1967 and published in Fed. Proc., 1967, 26: 490.
Identification
Copyright
© 1971 Published by Elsevier Inc.
