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Abstract
In short-term experiments in cockerels, elevation of plasma cholesterol from threshold
to excessively high levels induces coronary atherosclerosis in a curvilinear fashion
with the largest effect occurring in the lower ranges (from 100–500 mg/100 ml). Similar
increments of plasma cholesterol have a progressively smaller effect on coronary atherosclerosis
as the plasma cholesterol levels become higher. However, the results of long-term
experiments may differ from the short-term ones used in these experiments.
These experiments have a possible bearing on the efficacy of hypocholesterolemic procedures
clinically.
The nomogram established in this report can serve in this species (and at this age
and over this duration of the experiment) to distinguish coronary atherogenesis dependent
on hypercholesterolemia (per se) from that produced independently by the agent or
procedure employed.
Keywords
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References
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Article Info
Publication History
Received:
February 17,
1971
Footnotes
☆This work was supported by the National Heart Institute, Grant No. HE-06375 of the National Institute of Health, USPHS and the Chicago and American Heart Associations.
☆Some of this work was presented at the Federation of American Society for Experimental Biology, April 16–21, 1967 and published in Fed. Proc., 1967, 26: 490.
Identification
Copyright
© 1971 Published by Elsevier Inc.
