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The effects of pyridinolcarbamate on induced atherosclerosis in cynomolgus monkeys (Macaca ira)

  • M.R. Malinow
    Affiliations
    Department of Cardiovascular Physiology, Oregon Regional Primate Research Center, Beaverton, Oregon, and the University of Oregon Medical School, Portland, Oregon U.S.A.
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  • Phyllis McLaughlin
    Affiliations
    Department of Cardiovascular Physiology, Oregon Regional Primate Research Center, Beaverton, Oregon, and the University of Oregon Medical School, Portland, Oregon U.S.A.
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  • Anne Perley
    Affiliations
    Department of Cardiovascular Physiology, Oregon Regional Primate Research Center, Beaverton, Oregon, and the University of Oregon Medical School, Portland, Oregon U.S.A.
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      Abstract

      Atherosclerosis was induced in cynomolgus monkeys (Macaca iya) fed on a semipurified diet containing 0.5% cholesterol. No differences in the extent of aortic or coronary atherosclerosis were observed when pyridinolcarbamate (2–6 pyridine-dimethanol-bis (N-methylcarbamate)), was added to the diet at concentrations ranging from 400–2000 mg/kg food.

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