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Research paper| Volume 15, ISSUE 1, P77-82, January 1972

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Enzyme histochemical observations on the effect of pyridinol carbamate on cholesterol-induced atherosclerosis

  • M. Mottonen
    Affiliations
    Department of Forensic Medicine (Head: Professor Jyrki Raekallio), Department of Pathological Anatomy (Head: Professor Osmo Järvi), University of Turku, and Medical Research Laboratories (Lääke Ov and Medipolar Oy) (Head: Professor Kaarlo Hartiala), Turku Finland
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  • M. Pantio
    Affiliations
    Department of Forensic Medicine (Head: Professor Jyrki Raekallio), Department of Pathological Anatomy (Head: Professor Osmo Järvi), University of Turku, and Medical Research Laboratories (Lääke Ov and Medipolar Oy) (Head: Professor Kaarlo Hartiala), Turku Finland
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  • L. Nieminen
    Affiliations
    Department of Forensic Medicine (Head: Professor Jyrki Raekallio), Department of Pathological Anatomy (Head: Professor Osmo Järvi), University of Turku, and Medical Research Laboratories (Lääke Ov and Medipolar Oy) (Head: Professor Kaarlo Hartiala), Turku Finland
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DOI:https://doi.org/10.1016/0021-9150(72)90039-1
Enzyme histochemical observations on the effect of pyridinol carbamate on cholesterol-induced atherosclerosis
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      Abstract

      The effect of pyridinol carbamate on cholesterol-induced atherosclerosis in the rabbit was investigated in 28 animals. The diet was given for 8 months. The effect of pyridinol carbamate on lactate-NAD-tetrazolium reductase and ATPase activities of the abdominal and thoracic aortae was examined histochemically.
      The animals were divided into 4 dietary groups:
      • 1.
        1. regular diet (commercial rabbit food pellets, Orion)
      • 2.
        2. regular diet + pyridinol carbamate (100 mg/kg)
      • 3.
        3. regular diet + cholesterol (1 %)
      • 4.
        4. regular diet + cholesterol (1 %) + pyridinol carbamate (100 mg/kg).
      Lactate-NAD-tetrazolium reductase and ATPase were identical in the samples taken from the thoracic and abdominal aortae in all groups.
      No atherosclerotic formation was noted in dietary groups 1 and 2. Lactate-NAD-tetrazolium reductase and ATPase activities were identical in these two groups.
      Pyridinol carbamate was not observed to have any effect on lactate-NAD-tetrazolium reductase and ATPase activities of the aorta and atheroma plaques of the rabbit.

      Keywords

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      References

        • Adams C.W.M.
        Histochemistry of atherosclerosis correlated with structural and chemical pathology.
        in: Adams C.W.M. Vascular Histochemistyy. Lloyd-Luke (Medical Books), London1967: 83-177
        • Adams C.W.M.
        • Bayliss O.B.
        • Ibrahim M.Z.M.
        The distribution of lipids and enzymes in the aortic wall in dietary rabbit atheroma and human atherosclerosis.
        J. Pathol. Bacterial. 1963; 86: 421
        • Fouquet J.P.
        Dépot expérimental de cholestérol dans l'aorte du lapin, modifications histoenzymologiques corrélatives.
        Ann. Histochim. 1961; 6: 153
        • Hess R.
        • Scarpelli D.G.
        • Pearse A.G.E.
        The cytochemical localization of oxidative enzymes, Part 2 (Pyridine nucleotide-linked dehydrogenases).
        J. Biophys. Biochem. Cytol. 1958; 4: 753
        • Lojda W.
        Histochemistry of the vascular wall. Angiologia, cit. by C. W. M. Adams.
        in: Adams C.W.M. Vascular Histochemistyy. Lloyd-Luke (Medical Books), London1967
        • Lojda Z.
        • Felt V.
        The histochemistry of dehydrogenase systems in the aortae of rabbits with experimental atherosclerosis.
        Expeyientia (Basel). 1960; 16: 514
        • Malinow M.R.
        • Perley A.
        • McLaughlin Ph.A.
        Effects of pyrldlnolcarbamate on induced atherosclerosis in monkeys.
        Circulation. 1967; : 25
        • Shimamoto T.
        • Numano F.
        • Fujita T.
        • Ishioka T.
        • Atsumi T.
        Treatment of experimental and human atherosclerosis with pyridinolcarbamate: A preliminary report.
        Asian Med. J. 1965; 8: 825
        • Shimamoto T.
        • Numano F.
        • Fujita T.
        Atherosclerosis-inhibiting effect of an antibradykinin agent, pyridinol-carbamate.
        Amer. Heart J. 1966; 71: 216
        • Wachstein M.
        • Meisel E.
        Histochemistry of hepatic phosphatases at a physiological pH, with special reference to the demonstration of bile canaliculi.
        Amer. J. Clin. Pathol. 1957; 27: 13
        • Wegmann R.
        • Fouquet J.P.
        Quelques modifications histoenzymologiques accompagnant le début du dépot de cholestérol dans l'aorte du lapin.
        Ann. Histochim. 1961; 6: 61
        • Zemplényi T.
        • Lojda Z.
        • Mrhová O.
        Enzymes of the vascular wall in experimental atherosclerosis in the rabbit.
        in: Sandler M. Bourne G.H. Atherosclerosis and Its Origin. Academic Press, New York1963: 459-513

      Article info

      Publication history

      Received in revised form: May 13, 1971

      Footnotes

      ☆This work was supported by grants from the Sigrid Jusélius Foundation and from the National Research Council for Medical Sciences, Finland.

      Identification

      DOI: https://doi.org/10.1016/0021-9150(72)90039-1

      Copyright

      © 1971 Published by Elsevier Inc.

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