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Abstract
The effect of pyridinol carbamate on cholesterol-induced atherosclerosis in the rabbit
was investigated in 28 animals. The diet was given for 8 months. The effect of pyridinol
carbamate on lactate-NAD-tetrazolium reductase and ATPase activities of the abdominal
and thoracic aortae was examined histochemically.
The animals were divided into 4 dietary groups:
- 1.1. regular diet (commercial rabbit food pellets, Orion)
- 2.2. regular diet + pyridinol carbamate (100 mg/kg)
- 3.3. regular diet + cholesterol (1 %)
- 4.4. regular diet + cholesterol (1 %) + pyridinol carbamate (100 mg/kg).
Lactate-NAD-tetrazolium reductase and ATPase were identical in the samples taken from
the thoracic and abdominal aortae in all groups.
No atherosclerotic formation was noted in dietary groups 1 and 2. Lactate-NAD-tetrazolium
reductase and ATPase activities were identical in these two groups.
Pyridinol carbamate was not observed to have any effect on lactate-NAD-tetrazolium
reductase and ATPase activities of the aorta and atheroma plaques of the rabbit.
Keywords
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References
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Article info
Publication history
Received in revised form:
May 13,
1971
Footnotes
☆This work was supported by grants from the Sigrid Jusélius Foundation and from the National Research Council for Medical Sciences, Finland.
Identification
Copyright
© 1971 Published by Elsevier Inc.