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Effect of spinach and wakame on cholesterol turnover in the rat

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      Abstract

      The influence of feeding spinach or wakame on the turnover of cholesterol was studied in rats with a high plasma cholesterol level. The half-lives of cholesterol were estimated by measuring the faecal excretion of [3H] cholesterol injected intraperitoneally, and were found to be 28.2, 15.2 and 20.5 days, respectively, for rats fed the control sucrose diet, that supplemented with 5% spinach powder and that supplemented with 5% wakame powder. It is suggested from the analysis of faecal cholesterol metabolites that spinach stimulated the intestinal microflora to form more coprostanol from cholesterol, while wakame suppressed the reabsorption of cholesterol in the enterohepatic circulation.

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