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Abstract
Two groups of female and 2 groups of male miniature pigs (11 per group) were used
to study the effect of exercise on the development of atherosclerosis. The pigs were
maintained on a diet low in cholesterol and fat until 16 months of age at which time
this study was initiated. One pig was randomly selected from each group and necropsied
immediately before the study was initiated. The cardiovascular systems were examined
for atherosclerosis. None was found.
One group of each sex was trained and conditioned for sustained exercise on a treadmill.
When the animals were reasonably well conditioned after 3 weeks of exercise all groups
were fed an atherogenic diet. The trial was of 22 months duration.
Feeding the atherogenic ration increased the blood lipids in all groups. However,
the differences in the serum cholesterol, triglycerides, total lipids and plasma fibrinogen
between the groups of each sex were not significant. Differences between males and
females were significant. There were significant differences in the extent of atherosclerosis
between the exercised and the non-exercised pigs. Weight of the hearts in relation
to body weight was slightly greater in the exercised than in the non-exercised pigs
but the differences were not significant. This may have been due partly to the greater
amount of fat on hearts from non-exercised pigs. Coronary arteries were also slightly
larger in the non-exercised pigs. The exercised pigs consumed more of the diet, gained
less weight, had less atherosclerosis, and less total body fat than the non-exercised
pigs.
Keywords
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Article info
Publication history
Received in revised form:
June 30,
1971
Footnotes
☆This work was supported in part by Research Grant HE 07165 from the National Institutes of Health, Bethesda, Md.
Identification
Copyright
© 1971 Published by Elsevier Inc.
