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Abstract
l-[14C]Leucine was used to investigate the synthesis of serum lipoproteins in normal and
cholesterol-fed chickens. No radioactivity was present in the fasting serum VLDL fraction
from normal birds while a substantial amount of radioactivity remained in the same
fraction from cholesterol-fed animals, even 4 h after the injection of label. The
total incorporation of the label into LDL, HDL and serum proteins was not influenced
by the inclusion of cholesterol in the diet. Almost no activity was found in the VLDL
fraction of normal unfasted chickens during a 2 h period after the injection of label,
whereas a steadily increasing amount of radioactivity was observed during the same
time interval in the cholesterol-fed birds. As one possible explanation, it was proposed
that the large increase in the VLDL fraction observed in the cholesterol-fed chickens
as compared to the normal birds was due to a decreased rate of removal of this lipoprotein
from circulation.
Keywords
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References
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Article info
Publication history
Received:
April 28,
1971
Footnotes
☆This work was supported by a research grant from the Chicago and Illinois Heart Associations and a research career development award 5K3-CA-31, 063 to K. A. Narayan from U.S.P.H.S.
☆This work represents a portion of a thesis presented by A. W. Kruski, a partial fulfillment of the requirements for the Ph. D. degree at the University of Illinois.
Identification
Copyright
© 1972 Published by Elsevier Inc.