This paper is only available as a PDF. To read, Please Download here.
Abstract
l-[14C]Leucine was used to investigate the synthesis of serum lipoproteins in normal and
cholesterol-fed chickens. No radioactivity was present in the fasting serum VLDL fraction
from normal birds while a substantial amount of radioactivity remained in the same
fraction from cholesterol-fed animals, even 4 h after the injection of label. The
total incorporation of the label into LDL, HDL and serum proteins was not influenced
by the inclusion of cholesterol in the diet. Almost no activity was found in the VLDL
fraction of normal unfasted chickens during a 2 h period after the injection of label,
whereas a steadily increasing amount of radioactivity was observed during the same
time interval in the cholesterol-fed birds. As one possible explanation, it was proposed
that the large increase in the VLDL fraction observed in the cholesterol-fed chickens
as compared to the normal birds was due to a decreased rate of removal of this lipoprotein
from circulation.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to AtherosclerosisAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Aortic cholesterol and the plasma lipoproteins of the cholesterol-fed cockerel.in: Proc. Soc. exp. Biol. Med.130. 1969: 163
- Fatty acid composition of plasma and liver lipid components as influenced by diet in the growing chick.J. Nutr. 1963; 81: 357
- Lipid changes in plasma alpha lipoproteins, liver and aorta of chicks fed different fats.in: Proc. Soc. exp. Biol. Med.112. 1963: 300
- Isolation of plasma lipoproteins by zonal ultracentrifugation in the B14 and B15 titanium rotors.J. Lipid Res. 1970; 11: 7
- Characterization of chicken serum lipoproteins.in: Fed. Proc.28. 1969: 447
- The biosynthesis of plasma lipoproteins in higher animals.Comp. Biochem. Physiol. 1968; 25: 651
- The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.J. clip. Invest. 1955; 34: 1345
- Influence of Cholesterol on the Concentration, Composition and Synthesis of Chicken Serum Lipoprotein.in: Ph. D. Thesis. University of Illinois, Urbana1971
- Practical methods for plasma lipoprotein analysis.Adv. Lipid Res. 1968; 6: 1
- The role of cholesterol in the interaction of chyle and plasma.Quart. J. exp. Physiol. 1955; 40: 320
- Lipoprotein lipase of chicken adipose tissue.J. Biol. Chem. 1957; 226: 833
- Utilization of fat by chickens — A method for determining the absorption of nutrients.Poultry Sci. 1943; 22: 137
Article info
Publication history
Received:
April 28,
1971
Footnotes
☆This work was supported by a research grant from the Chicago and Illinois Heart Associations and a research career development award 5K3-CA-31, 063 to K. A. Narayan from U.S.P.H.S.
☆This work represents a portion of a thesis presented by A. W. Kruski, a partial fulfillment of the requirements for the Ph. D. degree at the University of Illinois.
Identification
Copyright
© 1972 Published by Elsevier Inc.
