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Muscular activity and the degradation of cholesterol by the liver

  • M.R. Malinow
    Affiliations
    Department of Cardiovascular Physiology, Oregon Regional Primate Research Center, Beaverton, Oreg., 97005, USA

    University of Oregon Medical School, Portland, Oreg. U.S.A.
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  • Phyllis McLaughlin
    Affiliations
    Department of Cardiovascular Physiology, Oregon Regional Primate Research Center, Beaverton, Oreg., 97005, USA

    University of Oregon Medical School, Portland, Oreg. U.S.A.
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  • Irene Pierovich
    Affiliations
    Department of Cardiovascular Physiology, Oregon Regional Primate Research Center, Beaverton, Oreg., 97005, USA

    University of Oregon Medical School, Portland, Oreg. U.S.A.
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      Abstract

      [1, 2 α-3H]Cholesterol lipoproteins were injected intravenously into bile-duct cannulated anesthetized rats; cholic [14C]carboxyl acid or radiopaque material was introduced into the small intestine. The animals also received intraenteric infusions of bile with or without whipping cream. Repeated contractions of the skeletal musculature increased the biliary secretion of products from the cyclic portion of the cholesterol molecule and of absorbed [14C]cholic acid without modifying intestinal motility.

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