The effect of simultaneous treatment with thyroxine and ascorbic acid precursors on serum cholesterol concentration

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      Male albino rats were actually treated with thyroxine and/or ascorbic acid and its biosynthetic precursors. The hypocholesteremic effect of thyroxine was exaggerated by simultaneous treatment with glucuronolactone. Treatment with either l-gulonolactone, 2-keto-l-gulonic acid or l-ascorbic acid protected the animals against the exogenously induced hyperthyroidism. No changes in the serum cholesterol concentrations were observed after treatment with only the precursors of ascorbic acid. The changes in serum cholesterol were attributed to alterations in the enterohepatic reabsorption of thyroxine.


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