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Hypolipidaemic activity of whole paddy in rats fed a high-fat-high-cholesterol diet

Isolation of an active fraction from the husk and bran
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      Abstract

      Whole ground paddy has been previously found to lower cholesterol and phospholipid in serum, liver and aorta of rats fed a high fat-cholesterol diet. A polysaccharide fraction has now been isolated from the defatted bran and husk of paddy; it has a remarkable lipid-lowering effect. The yield of the material is 0.33 g from 100 g of bran and hull. It contains 2.535 % N and 225 mg of uronic acid per 100 g. This substance keeps the total cholesterol and phospholipid of the serum, liver and aorta in rats fed the high fat-cholesterol diet at a similar low level to that in animals fed glucose. Rats receiving this substance had the lowest level of hepatic NAD-NADP, the highest level of myocardial lipoprotein lipase and a normal blood glucose level after an oral glucose load. Rats fed boiled rice showed lower lipid levels than rats fed unboiled rice.

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