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Abstract
When [3H]cholesterol was given orally to rats with thoracic lymph fistulas, the recovery
of radioactive cholesterol in lymph was about two-fold more in hypercholesteremic
rats than in the control during the first 6 h after administration. On the contrary,
in the intact rat (without lymph fistula), the recovery in plasma and liver at 6 h
was rather less in the hypercholesteremic group than in the control. As cholesterol
absorption in animals with the fistula was not influenced by the enterohepatic circulation
of cholesterol and bile acids, it might differ from that of the intact animal, especially
in the hypercholesteremic rat. This point should be considered in measuring cholesterol
absorption by thoracic lymph cannulation.
On the other hand, in the intact animal, cholesterol transport from plasma to liver
was also suppressed with increasing size of the cholesterol pool.
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References
- Absorption and distribution of cholesterol-414C in the rat.in: Proc. Soc. Exp. Biol. Med.99. 1958: 365
- The mechanism of cholesterol absorption.Ann. N.Y. A cad. Sci. 1959; 72: 813
- Influence of lactose feeding on cholesterol absorption and metabolism.J. Atheroscler. Res. 1969; 10: 207
- Techniques for the collection of lymph from liver, small intestine or thoracic duct of the rat.J. Lab. Clin. Med. 1948; 33: 1349
- Absorption and lymphatic transport of cholesterol in the rat.J. Lipid Res. 1968; 9: 596
Article info
Publication history
Received:
September 2,
1971
Identification
Copyright
© 1972 Published by Elsevier Inc.
