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Adaptive features in the turkey aorta which precede plaque formation

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      Abstract

      Posterior aortas taken from broad breasted white turkey poults were examined histologically in order to better define the early events which precede and accompany intimal plaque formation in this species. As early as 3 weeks after hatching, disproportionate thickenings appeared in the ventral portion of the outer aortic wall (outer media and adventitia). These thickenings were associated with a relative increase in non-elastic elements, especially collagen, and were found in over half the birds examined. Since the earliest recognizable intimal plaques made their appearance subsequent to and on the same side (ventral) of the aorta as the foregoing medial and adventitial features, there may be a causal relationship. The authors believe that these composite phenomena, perhaps initially adaptive and developmental in nature, may progress to a point where they weaken the wall to the extent that, by acting in conjunction with hypertension, aortic rupture can occur.

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      References

        • Clarkson T.B.
        Atherosclerosis-spontaneous and induced.
        in: Paoletti R. Kritchevsky D. Advances in Lipid Research. Academic Press, New York1963: 211-249
        • Ringer R.K.
        Aortic rupture, plasma cholesterol, and arteriosclerosis following serpasil administration to turkeys.
        in: Second Conference on the Use of Reserpine in Poultry Production, St. Paul, Minn.1960: 32-39 (Sponsor: Ciba Pharmac. Products, Inc., Summit, N.J.)
        • Waibel P.E.
        • Pomeroy B.S.
        Studies on the production of aortic hemorrhage in growing turkeys with beta-aminopropionitrile.
        Poultry Sci. 1958; 37: 934
        • Putt F.A.
        Flaming red as a dye for the demonstration of lipids.
        Lab. Invest. 1956; 5: 377
        • Movat H.Z.
        Demonstration of all connective tissue elements in a single section.
        Arch. Pathol. 1955; 60: 289
        • Zugibe F.T.
        Diagnostic Histochemistry.
        in: Mosby, St. Louis, Mo1970: 246
        • Middleton C.C.
        Naturally-occurring atherosclerosis in broad breasted bronze turkeys.
        in: Roberts J.C. Straus R. Cooper M.S. Comparative Atherosclerosis. Harper and Row, New York, N.Y1965: 59-61
        • Pritchard W.R.
        • Henderson W.
        • Beall C.W.
        Experimental production of dissecting aneurysms in turkeys.
        Amer. J. Vet. Res. 1958; 19: 696
        • Kurtz H.J.
        Aortic plaque degeneration as a cause of aortic rupture in turkeys.
        Amer. J. Vet. Res. 1969; 30: 251
        • Simpson C.F.
        • Harms R.H.
        The nature of the atherosclerosic plaque of the aorta of turkeys.
        J. Atheroscler. Res. 1968; 8: 143
        • Carnaghan R.B.A.
        Atheroma of the aorta associated with dissecting aneurysms in turkeys.
        Vet. Rec. 1955; 67: 568-569
        • Gibson E.A.
        • De Gruchy P.H.
        Aortic rupture in turkeys subsequent to dissecting aneurysm.
        Vet. Rec. 1955; 67: 650-654
        • Gresham G.A.
        • Howard A.N.
        Aortic rupture in the turkey.
        J. Atheroscler. Res. 1961; 1: 75
        • Gross J.
        Collagen.
        Sci. Amer. 1961; 204: 120
        • McDonald B.E.
        • Bird H.R.
        • Lalich J.J.
        The incidence of spontaneous pathologic changes in aortas of growing turkeys.
        Poultry Sci. 1964; 43: 341
        • Kurtz H.J.
        Aortic rupture in turkeys: lesions in tunica media and tunica adventitia associated with intimal plaques.
        Amer. J. Vet. Res. 1969; 30: 101
        • Altschul R.
        Selected Studies on Arteriosclerosis.
        in: Thomas, Springfield, Ill1950: 45-60
        • Ball R.A.
        A Study of Dissecting Aneurysm in the Turkey.
        (unpublished Ph. D. Thesis) University of Minnesota, 1964
        • Weiss H.S.
        • Sheahan M.
        The influence of maturity and sex on the blood pressure of the turkey.
        Amer. J. Vet. Res. 1958; 19: 209
        • Ringer R.K.
        • Rood K.
        Hemodynamic changes associated with aging in the broad breasted bronze turkey.
        Poultry Sci. 1959; 38: 395
        • Ringer R.K.
        The influence of reserpine on early growth, blood pressure, and dissecting aneurysms in turkeys.
        in: First Conference on the Use of Serpasil in Animal and Poultry Production. Rutgers University, New Brunswick, N.J1959: 21-28 (Sponsor: Ciba Pharmac. Products Inc., Summit, N.J.)
        • Krista L.M.
        • Waibel P.E.
        • Shoffner R.N.
        • Sautter J.H.
        Natural dissecting aneurysm (aortic rupture) and blood pressure in the turkey.
        Nature (Lond.). 1967; 214: 1162
        • Wissler R.W.
        • Vesselinovitch D.
        Experimental models of human atherosclerosis.
        Ann. N.Y. Acad. Sci. 1968; 149: 907
        • Ball R.A.
        • Sautter J.H.
        • Pomeroy B.S.
        • Waibel P.E.
        Natural and experimental dissecting aneurysms in turkeys.
        J. Pathol. Bacteriol. 1965; 89: 599