Advertisement

The effects of ligature of the thoracic duct on serum and liver lipids in normotensive and hypertensive rats

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      After development of an experimentally induced renal hypertension in rats, elevated concentrations of cholesterol and phospholipids in serum were observed. The additional ligature of the thoracic duct in normotensive and hypertensive animals further increased the lipid content of serum in hypertensive rats and promoted an even more severe hyperlipaemia in normotensive animals. In both experimental groups the hyperlipaemia took a biphasic course. The lipids measured approached their intitial values on the 15th day following the ligature of the ductus thoracicus. Moreover the ligature of the thoracic duct modified the total lipid content of the liver and induced pronounced morphological alterations of liver tissue.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Cremer H.
        • Müller N.
        • Bechtelsheimer H.
        Morphologische Untersuchungen an Leber und Dünndarm Bowie lipidchemische Untersuchungen im Serum nach Unterbindung des Ductus thoracicus bei Ratten.
        Virch. Arch. Abt. A Path. Anat. 1972; 355: 309
        • Schettler G.
        Lipids and Lipidoses.
        Springer, Berlin1967
        • Duncombe W.G.
        The colorimetric micro-determination of nonesterified fatty acids in plasma.
        Clin. Chim. Acta. 1964; 9: 122
        • Fletcher M.J.
        A colorimetric method for estimating serum triglycerides.
        Clin. Chim. Acta. 1968; 22: 393
        • Richterich R.
        • Lauber K.
        Bestimmung des Gesamt-Cholesterins im Serum. VIII. Mitteilung über Ultramikromethoden im klinischen Laboratorium.
        Klin. Wschr. 1962; 40: 1252
        • Whitley R.W.
        • Alburn H.E.
        Halbautomatisches Verfahren zur Bestimmung der Serum-Phospholipide.
        in: Technicon GmbH, Frankfurt1964: 308 (Sonderdruck)
        • Gross F.
        Der erhöhte Blutdruck; Experimentelle Hypertonie.
        in: Heintz R. Losse H. Arterielle Hypertonie. Thieme, Stuttgart1969: 63