Hypolipidaemic principle of the husk and bran of paddy nature of the substance and its effect on cholesterol absorption and faecal bile salt excretion in rats fed a high-fat-high-cholesterol diet

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      The effect of oral administration of varying doses of a polysaccharide fraction isolated from bran and husk of paddy on the cholesterol, phospholipid and triglyceride levels of the serum, liver and aorta in rats fed a high-fat-high-cholesterol diet has been studied. At a daily dose of 15 mg per rat per day, these levels were comparable to those in rats fed a normal diet. The substance, while having no appreciable effect on cholesterol absorption, considerably increased the breakdown of cholesterol to bile salts and caused increased faecal bile salt excretion. The polysaccharide fraction contains 41.53% carbohydrate, 7.48% uronic acid, 0.54% hexosamine, 22.03 proteins, 1.78 % sulphate and 4.3 % acetyl groups. It is found to contain two components one precipitable by cetylpyridinium chloride (42%) and the other not precipitable (58%).


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