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Inhibition of cyclic amp formation and lipolysis in rat adipose tissue by nicotinic acid

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      Abstract

      In perirenal adipose tissue from rat both noradrenaline and theophylline stimulated the glycerol-release and increased the content of cyclic AMP in the tissue as well as in the incubation medium. Nicotinic acid blocked or reduced the submaximally lipolytic effect of both noradrenaline and theophylline ; the effect of theophylline being most sensitive to nicotinic acid inhibition. In concentrations where nicotinic acid almost completely blocked the lipolytic actions of noradrenaline or theophylline, nicotinic acid also blocked the increasing action of the drugs on the cyclic AMP level. Nicotinic acid did not reduce the basal glycerol release or cyclic AMP content.

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