Advertisement

Plasma lipoproteins of turkeys injected with a single dose of diethylstilbestrol

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Turkeys injected with a single dose of diethylstilbestrol (DES) (15, 30 or 60 mg) develop a hyperlipoproteinemia which is characterized by a large increase in chylomicrons, a weak pre-beta lipoprotein concentration and an absence of beta- and alpha-lipoproteins. The hyperlipoproteinemia was pronounced between 3 and 12 days post injection. The rate and degree of development of the induced hyperlipoproteinemia is similar for the 3 levels of DES injected. Increased concentrations of cholesterol and protein are found in the low-density lipoproteins (LDL) between 4 and 20 days post injection, while the cholesterol and protein content of the high-density lipoproteins (HDL) are greatly reduced. The levels of cholesterol and protein in the LDL HDL HDL return to normal on day 44 post injection.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Simpson C.F.
        • Harms R.H.
        Pathology of aortic atherosclerosis and dissecting aneurysms of turkeys induced by diethylstilbestrol.
        Exp. Mol. Path. 1966; 5: 183
        • Simpson C.F.
        • Harms R.H.
        Aortic dissecting aneurysms.
        Adv. Vet. Sci. Comp. Med. 1969; 13: 1
        • Simpson C.F.
        • Harms R.H.
        Comparison of parenterally and orally administered diethylstilbestrol in production of aortic ruptures in turkeys.
        in: Proc. Soc. Exp. Biol. Med.122. 1966: 1162
        • Simpson C.F.
        • Harms R.H.
        • Kling J.M.
        Relationship of dietary sodium chloride to aortic ruptures in turkeys induced by diethylstilbestrol.
        in: Proc. Soc. Exp. Biol. Med.121. 1966: 633
        • Simpson C.F.
        • Neilson J.T.M.
        Aortic atherosclerosis of turkeys induced by a single treatment with diethylstilbestrol.
        Atherosclerosis. 1973; 17: 245
        • Simpson C.F.
        • Neilson J.T.M.
        • Harms R.H.
        Reduction of incidence of diethylstilbestrol induced aortic ruptures of turkeys with mithimazole.
        Tox. Applied Pharmacol. 1971; 20: 412
        • Frings C.S.
        • Foster L.B.
        • Cohen P.S.
        Electrophoretic separation of serum lipoproteins in polyacrylamide gel.
        Clin. Chem. 1971; 17: 111
        • Levine J.B.
        • Zak B.
        Automated determination of serum total cholesterol.
        Clin. Chim. Acta. 1964; 10: 381
        • Kabat E.A.
        • Mayer M.M.
        Experimental Immunochemistry.
        in: Thomas, Springfield, Ill1960: 476-483
        • Thompson S.W.
        • Hunt R.D.
        Selected Histochemical and Histopathological Methods.
        in: Thomas, Springfield, Ill1966
        • Furman R.H.
        Are gonadal hormones (estrogens and androgens) of significance in the development of ischemic heart disease?.
        Ann. N.Y. Acad. Sci. 1968; 149: 822