Plasma lipoproteins of turkeys injected with a single dose of diethylstilbestrol

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      Turkeys injected with a single dose of diethylstilbestrol (DES) (15, 30 or 60 mg) develop a hyperlipoproteinemia which is characterized by a large increase in chylomicrons, a weak pre-beta lipoprotein concentration and an absence of beta- and alpha-lipoproteins. The hyperlipoproteinemia was pronounced between 3 and 12 days post injection. The rate and degree of development of the induced hyperlipoproteinemia is similar for the 3 levels of DES injected. Increased concentrations of cholesterol and protein are found in the low-density lipoproteins (LDL) between 4 and 20 days post injection, while the cholesterol and protein content of the high-density lipoproteins (HDL) are greatly reduced. The levels of cholesterol and protein in the LDL HDL HDL return to normal on day 44 post injection.


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        • Simpson C.F.
        • Harms R.H.
        Pathology of aortic atherosclerosis and dissecting aneurysms of turkeys induced by diethylstilbestrol.
        Exp. Mol. Path. 1966; 5: 183
        • Simpson C.F.
        • Harms R.H.
        Aortic dissecting aneurysms.
        Adv. Vet. Sci. Comp. Med. 1969; 13: 1
        • Simpson C.F.
        • Harms R.H.
        Comparison of parenterally and orally administered diethylstilbestrol in production of aortic ruptures in turkeys.
        in: Proc. Soc. Exp. Biol. Med.122. 1966: 1162
        • Simpson C.F.
        • Harms R.H.
        • Kling J.M.
        Relationship of dietary sodium chloride to aortic ruptures in turkeys induced by diethylstilbestrol.
        in: Proc. Soc. Exp. Biol. Med.121. 1966: 633
        • Simpson C.F.
        • Neilson J.T.M.
        Aortic atherosclerosis of turkeys induced by a single treatment with diethylstilbestrol.
        Atherosclerosis. 1973; 17: 245
        • Simpson C.F.
        • Neilson J.T.M.
        • Harms R.H.
        Reduction of incidence of diethylstilbestrol induced aortic ruptures of turkeys with mithimazole.
        Tox. Applied Pharmacol. 1971; 20: 412
        • Frings C.S.
        • Foster L.B.
        • Cohen P.S.
        Electrophoretic separation of serum lipoproteins in polyacrylamide gel.
        Clin. Chem. 1971; 17: 111
        • Levine J.B.
        • Zak B.
        Automated determination of serum total cholesterol.
        Clin. Chim. Acta. 1964; 10: 381
        • Kabat E.A.
        • Mayer M.M.
        Experimental Immunochemistry.
        in: Thomas, Springfield, Ill1960: 476-483
        • Thompson S.W.
        • Hunt R.D.
        Selected Histochemical and Histopathological Methods.
        in: Thomas, Springfield, Ill1966
        • Furman R.H.
        Are gonadal hormones (estrogens and androgens) of significance in the development of ischemic heart disease?.
        Ann. N.Y. Acad. Sci. 1968; 149: 822