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Abstract
The amounts of soluble, fibrinogen/fibrin related antigens (FRA) and of intact low-density
(LD) lipoprotein in human aortic intima have been measured by an immunoelectrophoretic
technique. Substantial amounts of FRA and LD lipoprotein were found in normal intima:
in early fibrous lesions the concentrations of both antigens showed two- to four-fold
increases compared with normal intima from the same aorta.
In spite of the increase in concentration the ratio LD lipoprotein cholesterol/FRA
did not differ significantly between normal intima and lesions. There was a significant
correlation between lipoprotein and FRA (r = 0.722, P = 0.015), which suggests that fibrinogen may be entering the intima together with
lipoprotein and other plasma constituents. When tissue samples were treated with thrombin
about 50% of the antigen was “clotted”; the “clottable” material was presumably fibrinogen
since “clottable” fragments are not derived from lysis of a stabilized fibrin clot.
The results suggest that substantial amounts of plasma fibrinogen enter the intima;
if this is converted to fibrin within the intimal tissue it could be a potent factor
in atherogenesis.
Keywords
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Article info
Publication history
Received:
January 14,
1973
Footnotes
☆This work was carried out with the aid of a grant from the British Heart Foundation to whom the authors are extremely grateful.
Identification
Copyright
© 1973 Published by Elsevier Inc.
