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Lipid metabolism in perfused human nonatherosclerotic coronary arteries and saphenous veins

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      Abstract

      The experiments dealt with lipid synthesis and cholesterol uptake in human coronary arteries without evidence of atherosclerosis and in human saphenous veins perfused in vitro with pulsatile pressure. The results demonstrate the following:
      • 1.
        1. Human coronary arteries without evidence of atherosclerosis and atherosclerotic coronary arteries are unable to synthesize cholesterol from acetate.
      • 2.
        2. Synthesis of cholesterol esters is small in coronary arteries regardless of the presence or absence of atherosclerotic lesions.
      • 3.
        3. Identical uptakes of cholesterol were found in normal and atherosclerotic coronary arteries.
      • 4.
        4. Lipid synthesis in human saphenous veins perfused at a pressure of Math Eq Hg does not differ from that in nonatherosclerotic coronary arteries or saphenous veins perfused at a pressure of Math Eq.
      • 5.
        5. Cholesterol uptake in saphenous veins perfused at a pressure of Math Eq is lower than that in coronary arteries or saphenous veins perfused at arterial pressure (Math Eq.

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