Advertisement

Comparison of arterial lesions and serum lipids in spider and rhesus monkeys on an egg and butter diet

  • W.P. Newman III
    Affiliations
    Department of Pathology, Louisiana State University Medical Center, 1542 Tulane Avenue, New Orleans, La. 70112 U.S.A.
    Search for articles by this author
  • D.A. Eggen
    Correspondence
    Reprint requests to Dr. Douglas A. Eggen, Department of Pathology, Louisiana State University Medical Center, 1542 Tulane Avenue, New Orleans, La. 70112, U.S.A.
    Affiliations
    Department of Pathology, Louisiana State University Medical Center, 1542 Tulane Avenue, New Orleans, La. 70112 U.S.A.
    Search for articles by this author
  • J.P. Strong
    Affiliations
    Department of Pathology, Louisiana State University Medical Center, 1542 Tulane Avenue, New Orleans, La. 70112 U.S.A.
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Serum and aortic lipids and atherosclerotic lesions were studied in five spider monkeys (Ateles sp.) and three rhesus monkeys (Macaca mulatta) after changing from a commercial chow diet to a high fat (40% of calories), high cholesterol (1 mg/cal), semisynthetic diet containing egg yolk and butter. There was a large species difference in response of serum cholesterol. After 12 weeks on the diet the mean elevation of serum cholesterol was 285 mg/100 ml for the rhesus and 17 mg/100 ml for the spider monkeys. Changes in serum cholesterol ester fatty acid patterns were also very much greater for the rhesus than for the spider monkey. Aortas and coronary arteries of the rhesus were extensively involved with sudanophilic lesions. The cholesterol and cholesterol ester content of the aortic intima was much greater in the rhesus than in the spider monkey. The proportional contribution of aortic cholesterol oleate was greater in rhesus than spider monkeys and the palmitate was lower. There were only a few sudanophilic lesions in the coronary arteries of the spider monkeys. The coronary arteries of one older rhesus monkey were extensively involved with fibrous lesions. There was no appreciable difference between species in the histologic appearance of the sudanophilic lesions.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Taylor C.B.
        Experimentally induced atherosclerosis in nonhuman primates.
        in: Roberts J.C. Straus R. Comparative Atherosclerosis. Harper and Row, New York, N.Y1965: 215
        • Gresham G.A.
        • Howard A.N.
        Vascular lesions in primates.
        Ann. N. Y. Acad. Sci. 1965; 127: 694
        • Portman O.W.
        • Andrus S.B.
        Comparative evaluation of three species of New World monkeys for studies of dietary factors, tissue lipids, and atherogenesis.
        J. Nutr. 1965; 87: 429
        • Wissler R.W.
        Recent progress in studies of experimental primate atherosclerosis.
        in: Miras C.J. Howard A.N. Paoletti R. Progress in Biochemical Pharmacology. Karger, Basel, New York1968: 378
        • Strong J.P.
        • Eggen D.A.
        • Newman III, W.P.
        • Martinez R.D.
        Naturally occurring and experimental atherosclerosis in primates.
        Ann. N. Y. Acad. Sci. 1968; 149: 882
        • Eggen D.A.
        • Strong J.P.
        • Newman II, W.P.
        Experimental atherosclerosis in primates: A comparison of selected species.
        Ann. N.Y. Acad. Sci. 1969; 162: 110
        • Abell L.L.
        • Levy B.B.
        • Brodie B.B.
        • Kendall F.E.
        A simplified method for the experimentation of total cholesterol in serum and demonstration of its specificity.
        J. Biol. Chem. 1952; 195: 367
        • Strong J.P.
        • McGill Jr., H.C.
        Diet and experimental atherosclerosis in baboons.
        Amer. J. Pathol. 1967; 50: 669
        • Spurlock B.O.
        • Skinner M.S.
        • Kattine A.A.
        A simple rapid method for staining epoxy-embedded specimens for light microscopy with the polychromic stain Paragon-1301.
        Amer. J. Clin. Pathol. 1966; 46: 252
        • Sperry W.M.
        The relationship between total and free cholesterol in human blood serum.
        J. Biol. Chem. 1936; 114: 125
        • Leonard P.J.
        • Shaper A.G.
        • Jones K.W.
        Relationship between free and total cholesterol values in human serum.
        Amer. J. Clin. Nutr. 1965; 17: 377
        • Taylor C.B.
        • Cox G.E.
        • Estrella P.M.
        • Southworth J.
        Atherosclerosis in rhesus monkeys, Part 2 (Arterial lesions associated with hypercholesteremia induced by dietary fat and cholesterol).
        Arch. Pathol. 1962; 74: 16
        • Wissler R.W.
        • Getz G.S.
        • Vesselinovitch P.
        • Frazier L.E.
        • Hughes R.H.
        Acute severe experimental atherosclerosis in rhesus monkeys.
        in: Fed. Proc.25. 1966: 597
        • Scott R.F.
        • Morrison E.S.
        • Jarmolych J.
        • Nam S.C.
        • Kroms M.
        • Coulston F.
        Experimental atherosclerosis in rhesus monkeys, Part 1 (Gross and light microscopy features and lipid values in serum and aorta).
        Exp. Mol. Pathol. 1967; 7: 11
        • Wissler R.W.
        • Hughes R.H.
        • Frazier L.E.
        • Getz G.S.
        • Turner D.F.
        Aortic lesions and blood lipids in rhesus monkeys fed “table-prepared” human diets.
        Circulation. 1965; 32 (4): 220
        • Lofland H.B.
        • St. Clair R.W.
        • Macnintch J.E.
        • Pritchard R.W.
        Atherosclerosis in New World primates: Biochemical studies.
        Arch. Pathol. 1967; 83: 211
        • Chawla K.K.
        • Murthy C.D.S.
        • Chakravarti R.N.
        • Chuttani P.N.
        Arteriosclerosis and thrombosis in wild rhesus monkeys.
        Amer. Heart J. 1967; 73: 85
        • Lindsay S.
        • Chaikoff I.L.
        Naturally occurring arteriosclerosis in nonhuman primates.
        J. Atheroscler. Res. 1966; 6: 36
        • Lofland H.B.
        • Clarkson T.B.
        • Bullock B.C.
        Whole body sterol metabolism in squirrel monkeys.
        Exp. Mol. Pathol. 1970; 13: 1
        • Manning P.J.
        • Clarkson T.B.
        • Lofland H.B.
        Cholesterol absorption, turnover and excretion rates in hypercholesteremic rhesus monkeys.
        Exp. Mol. Pathol. 1971; 14: 75
        • Blaton V.
        • Howard A.N.
        • Gresham G.A.
        • Vandamme D.
        • Peeters H.
        Lipid changes in the plasma lipoproteins of baboons given an atherogenic diet, Part 1 (Changes in the lipids of total plasma and of α- and β-lipoproteins).
        Atherosclerosis. 1970; 11: 497