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In a long-term investigation the serum cholesterol level was lowered with the aid of an exchange of dietary saturated fatty acids for polyunsaturated fatty acids. After 6 years of diet, the experimental and control populations were reversed. Blood coagulation tests were made both before and after reversal of the diets. Whole blood clotting time (WBCT) and stypven time were determined twice, heparin tolerance time (HTT) and fibrinolysis in euglobulins only prior to the reversal of the diet. 150 male subjects were included in the first phase of the study; 129 of them were available for the second phase.
On both occasions, the stypven time was shorter in the same group, in spite of the intervening reversal of the diets. There was no difference in WBCT and HTT, but the fibrinolysis was shorter in the control group. The intraindividual changes diverged: WBCT became more prolonged in the group changing from polyunsaturated to saturated fat intake, while stypven time was shortened more among the same group.
WBCT was positively correlated with cholesterol and lipid phosphorus. Stypven time had negative correlations with relative body weight (RBW), systolic and diastolic blood pressure, and with serum cholesterol, triglyceride and lipid phosphorus. HTT was also negatively correlated with systolic pressure. Fibrinolysis time showed positive correlations with RBW, cholesterol and triglycerides.
The observed lower incidence of ischemic heart disease in the group on the polyunsaturated diet evidently was not mediated by any changes in blood coagulability revealed by the tests used.
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Received: February 27, 1973
☆Supported by National Heart Institute Research Grant HE-08176.
© 1974 Published by Elsevier Inc.