Advertisement
Research paper| Volume 19, ISSUE 1, P87-101, January 1974

Blood coagulation studies in a long-term experiment on dietary prevention of ischemic heart disease

DOI:https://doi.org/10.1016/0021-9150(74)90046-X
Blood coagulation studies in a long-term experiment on dietary prevention of ischemic heart disease
Previous ArticleComparison of arterial lesions and serum lipids in spider and rhesus monkeys on an egg and butter diet
Next ArticleThe effect of d-thyroxine on the metabolism of cholesterol in familial hyperbetalipoproteinaemia
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      In a long-term investigation the serum cholesterol level was lowered with the aid of an exchange of dietary saturated fatty acids for polyunsaturated fatty acids. After 6 years of diet, the experimental and control populations were reversed. Blood coagulation tests were made both before and after reversal of the diets. Whole blood clotting time (WBCT) and stypven time were determined twice, heparin tolerance time (HTT) and fibrinolysis in euglobulins only prior to the reversal of the diet. 150 male subjects were included in the first phase of the study; 129 of them were available for the second phase.
      On both occasions, the stypven time was shorter in the same group, in spite of the intervening reversal of the diets. There was no difference in WBCT and HTT, but the fibrinolysis was shorter in the control group. The intraindividual changes diverged: WBCT became more prolonged in the group changing from polyunsaturated to saturated fat intake, while stypven time was shortened more among the same group.
      WBCT was positively correlated with cholesterol and lipid phosphorus. Stypven time had negative correlations with relative body weight (RBW), systolic and diastolic blood pressure, and with serum cholesterol, triglyceride and lipid phosphorus. HTT was also negatively correlated with systolic pressure. Fibrinolysis time showed positive correlations with RBW, cholesterol and triglycerides.
      The observed lower incidence of ischemic heart disease in the group on the polyunsaturated diet evidently was not mediated by any changes in blood coagulability revealed by the tests used.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Turpeinen O.
        • Miettinen M.
        • Karvonen M.J.
        • Roine P.
        • Pekkarinen M.
        • Lehtosuo E.J.
        • Alivirta P.
        Dietary prevention of coronary heart disease: long-term experiment, Part 1 (Observations on male subjects).
        Amer. J. Clin. Nutr. 1968; 21: 255
        • Buzina R.
        • Karvonen M.J.
        • Roine P.
        • Turpeinen O.
        Effect of changes in dietary fat on whole-blood coagulation time in man.
        Lancet. 1961; ii: 287
        • Karvonen M.J.
        • Turpeinen O.
        • Roine P.
        Arterial pressure, relative body-weight and stypven-time.
        Lancet. 1969; i: 680
        • Buzina R.
        • Keys A.
        Blood coagulation after fat meal.
        Circulation. 1956; 14: 854
        • Soulier J.P.
        • Le Bolloch A.G.
        ‘In vitro’ herapin tolerance test in control of dicumarol therapy.
        Acta Med. Scand. 1951; 140: 132
        • Maclagan N.F.
        • Billimoria J.D.
        • Curtis C.
        Lipaemia and blood coagulation with special reference to the stypven technique.
        Lancet. 1958; ii: 865
        • Copley A.L.
        • Niewiakowski S.
        • Marechal J.
        A micromethod of euglobulin fibrinolysis in plasma of human subjects and small laboratory animals.
        J. Lab. Clin. Med. 1959; 53: 468
      8. Build and Blood Pressure Study. Vol. 1. Society of Actuaries, Chicago1959
        • James D.C.O.
        • Drysdale J.
        • Billimoria J.D.
        • Wheatley D.
        • Gavey C.P.
        • Maclagan N.F.
        Lipaemia and blood-coagulation defects in relation to ischaemic heart-disease.
        Lancet. 1961; ii: 798
        • Howell M.
        Effects of plasma lipids on fibrinolysis.
        Brit. Med. Bull. 1964; 20: 200
        • Rifkind B.M.
        • Dubber A.H.C.
        • Gale M.
        • McNicol G.P.
        • Douglas A.S.
        Serum triglyceride levels and stypven-time.
        Lancet. 1966; i: 745
        • Shaper A.G.
        • Jones K.W.
        • Kyobe J.
        • Jones M.
        Fibrinolysis in relation to body fatness, serum lipids and coronary heart disease in African and Asian men in Uganda.
        J. Atheroscler. Res. 1966; 6: 313
        • Sweet B.
        • Rifkind B.M.
        • McNicol G.P.
        The relationship between blood lipids and the fibrinolytic enzyme system.
        J. Atheroscler. Res. 1966; 6: 359
        • Rifkind B.M.
        • Gale M.
        Stypven time and serum triglyceride levels in fasting subjects.
        J. Atheroscler. Res. 1967; 7: 704
        • Turpeinen O.
        • Miettinen M.
        • Karvonen M.J.
        • Roine P.
        • Pekkarinen M.
        • Lehtosuo E.J.
        • Alivirta P.
        Blood lipids and primary coronary events.
        Minn. Med. 1969; 52: 1247
        • Ahrens Jr, E.H.
        • Hirsch J.
        • Oette K.
        • Farquhar J.W.
        • Stein Y.
        Carbohydrateinduced and fat-induced lipemia.
        Trans. Ass. Amer. Phycns. 1961; 74: 134
        • Miettinen M.
        Fibrinolysis, its diurnal variation and effect of dietary fat.
        Work-Environm. Hlth. 1971; 8: 46
        • Miettinen M.
        Effect of changes in dietary fat on fibrinolysis in elderly women.
        Work-environm. Hlth. 1971; 8: 49
        • Goldrick R.B.
        • Whyte H.M.
        Serum lipoproteins and blood coagulation.
        Nature (London). 1958; 182: 1743
        • Konttinen Y.
        Fibrinolysis, Chemistry, Physiology, Pathology and Clinics.
        in: Star Pharmaceutical Manufacturers, Tampere1968: 375-382
        • Nestel P.J.
        Fibrinolytic activity of the blood in intermittent claudication.
        Lancet. 1959; ii: 373
        • Nestel P.J.
        The relationship between blood fibrinolytic activity, serum lipoproteins and serum cholesterol in atherosclerotic arterial disease.
        Aust. Ann. Med. 1960; 9: 234
        • Goldrick R.B.
        Fibrinolysis, blood clotting, serum lipids and body build in natives of New Guinea and Australians.
        Aust. Ann. Med. 1961; 10: 20
        • Ogston D.
        Serum mucoproteins and plasma fibrinolytic activity in coronary-artery disease.
        Brit. Med. J. 1962; i: 1242
        • Shaw D.A.
        • MacNaughton D.
        Relationship between blood fibrinolytic activity and body fatness.
        Lancet. 1963; i: 352
        • Ogston D.
        • McAndrew G.M.
        Fibrinolysis in obesity.
        Lancet. 1964; ii: 1205
        • Chahrabarti R.
        • Hocking E.D.
        • Fearnley G.R.
        • Mann R.D.
        • Attwell T.N.
        • Jackson D.
        Fibrinolytic activity and coronary-artery disease.
        Lancet. 1968; ii: 987
        • Hicks K.E.
        Changes in the blood-clotting mechanism, serum lipids, and basal blood pressure in Antarctica.
        Clin. Sci. 1967; 33: 527
        • Rozgon G.L.
        Blood coagulation in patients with hypertensive disease.
        Vračebnoe Delo (Kiev). 1966; : 23
        • Andrustsshenko E.V.
        • Mansurov T.
        Pro jemini v sistemi jesidannja krovi y tvarin je eksperimentalnoju gipertonieju.
        Fiziol. Zh. (Kiev). 1966; 12: 93

      31. Karvonen M.J., To be published.

      32. Punsar, S., To be published.

        • Korsan-Bengtsen F.
        Koagulationseffekter och rökning.
        Läkartidningen. 1970; 67: 60
        • Menon I.S.
        Fibrinolytic activity in the blood of 99 healthy young British, African and Asian subjects.
        Lab. Pract. 1968; 17: 194
        • Engelberg H.
        Cigarette smoking and the in vitro thrombosis of human blood.
        J. Amer. Med. Ass. 1965; 193: 1033
        • Engelberg H.
        • Futterman M.
        Cigarette smoking and thrombotic coagulation of human blood.
        Arch. Environ. Health. 1967; 14: 266
        • Sogani R.K.
        • Jashi K.C.
        Effect of cigarette and biri smoking and tobacco chewing on blood coagulation and fibrinolytic activity.
        Indian Heart J. 1965; 17: 238
        • Murphy E.A.
        • Mustard J.F.
        Tobacco and thrombosis.
        Amer. J. Publ. Health. 1966; 56: 1061

      Article info

      Publication history

      Received: February 27, 1973

      Footnotes

      ☆Supported by National Heart Institute Research Grant HE-08176.

      Identification

      DOI: https://doi.org/10.1016/0021-9150(74)90046-X

      Copyright

      © 1974 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX