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Abstract
The effect of d-thyroxine plus propranolol on cholesterol metabolism was investigated in three patients
with familial hyperbetalipoproteinaemia whose plasma cholesterol was labelled with
[14C]cholesterol. In each patient the treatment caused a fall in plasma cholesterol concentration
and a temporary increase in faecal excretion of endogenous steroids, due to increased
output of neutral steroids in two patients and to increased output of bile acids in
the third patient. The cumulative increase in output of endogenous steroids during
treatment was greater than the amount of cholesterol lost from the plasma. Since the
specific radioactivity curve of the plasma cholesterol did not indicate increased
synthesis of cholesterol during the treatment, it was concluded that cholesterol mobilized
from the tissues, as well as plasma cholesterol, contributed to the increase in faecal
excretion of endogenous steroids.
Keywords
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Article info
Publication history
Received:
February 6,
1973
Identification
Copyright
© 1974 Published by Elsevier Inc.
