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Oxygen diffusion and atherosclerosis

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      Abstract

      The intramuscular injection of the carotenoid compound, Cocetin, in rabbits fed an atherosclerosis-producing diet, resulted in greatly reduced severity of the atherosclerosis. In addition, serum cholesterol levels were reduced by 50%. Crocetin also causes increased oxygen diffusion through the blood plasma. Thus, these results would appear to add evidence that hypoxia, due to reduced diffusion of oxygen at the blood-tissue interface, plays an important and perhaps an initiating part in the pathogenesis of atherosclerosis.

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